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The explosion in text-to-image AI models like OpenAI’s DALL-E 2—programs trained to generate pictures of almost anything you ask for—has sent ripples through the creative industries, from fashion to filmmaking, by providing weird and wonderful images on demand.

The same technology behind these programs is also making a splash in biotech labs, which are increasingly using this type of generative AI, known as a diffusion model, to conjure up designs for new types of protein never seen in nature.

Today, two labs separately announced programs that use diffusion models to generate designs for novel proteins with more precision than ever before. Generate Biomedicines, a Boston-based startup, revealed a program called Chroma, which the company describes as the “DALL-E 2 of biology.”

At the same time, a team at the University of Washington led by biologist David Baker has built a similar program called RoseTTAFold Diffusion. In a preprint paper posted online today, Baker and his colleagues show that their model can generate precise designs for novel proteins that can then be brought to life in the lab. “We’re generating proteins with really no similarity to existing ones,” says Brian Trippe, one of the co-developers of RoseTTAFold.

These protein generators can be directed to produce designs for proteins with specific properties, such as shape or size or function. In effect, this makes it possible to come up with new proteins to do particular jobs on demand. Researchers hope that this will eventually lead to the development of new and more effective drugs. “We can discover in minutes what took evolution millions of years,” says Gevorg Grigoryan, CEO of Generate Biomedicines.

“What is notable about this work is the generation of proteins according to desired constraints,” says Ava Amini, a biophysicist at Microsoft Research in Cambridge, Massachusetts.

symmetry thumbnail 1 1
Symmetrical protein structures generated by ChromaGENERATE BIOMEDICINES

Proteins are the fundamental building blocks of living systems. In animals, they digest food, contract muscles, detect light, drive the immune system, and so much more. When people get sick, proteins play a part.

Proteins are thus prime targets for drugs. And many of today’s newest drugs are protein based themselves. “Nature uses proteins for essentially everything,” says Grigoryan. “The promise that offers for therapeutic interventions is really immense.”

But drug designers currently have to draw on an ingredient list made up of natural proteins. The goal of protein generation is to extend that list with a nearly infinite pool of computer-designed ones.

Computational techniques for designing proteins are not new. But previous approaches have been slow and not great at designing large proteins or protein complexes—molecular machines made up of multiple proteins coupled together. And such proteins are often crucial for treating diseases.

Oligomer Density 1
A protein structure generated by RoseTTAFold Diffusion (left) and the same structure created in the lab (right)IAN C HAYDON / UW INSTITUTE FOR PROTEIN DESIGN

The two programs announced today are also not the first use of diffusion models for protein generation. A handful of studies in the last few months from Amini and others have shown that diffusion models are a promising technique, but these were proof-of-concept prototypes. Chroma and RoseTTAFold Diffusion build on this work and are the first full-fledged programs that can produce precise designs for a wide variety of proteins.

Namrata Anand, who co-developed one of the first diffusion models for protein generation in May 2022, thinks

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By: Will Douglas Heaven
Title: Biotech labs are using AI inspired by DALL-E to invent new drugs
Sourced From: www.technologyreview.com/2022/12/01/1064023/biotech-labs-are-using-ai-inspired-by-dall-e-to-invent-new-drugs/
Published Date: Thu, 01 Dec 2022 18:37:38 +0000

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How Antarctica’s history of isolation is ending—thanks to Starlink

Mawson and sledge Adelie Land Antarctica 1912 scaled

“This is one of the least visited places on planet Earth and I got to open the door,” Matty Jordan, a construction specialist at New Zealand’s Scott Base in Antarctica, wrote in the caption to the video he posted to Instagram and TikTok in October 2023.

In the video, he guides viewers through an empty, echoing hut, pointing out where the men of Ernest Shackleton’s 1907 expedition lived and worked—the socks still hung up to dry and the provisions still stacked neatly in place, preserved by the cold.

Jordan, who started making TikToks to keep family and friends up to date with his life in Antarctica, has now found himself at the center of a phenomenon. His channels have over a million followers. The video of Shackleton’s hut alone has racked up millions of views from all over the world. It’s also kind of a miracle: until very recently, those who lived and worked on Antarctic bases had no hope of communicating so readily with the outside world.

Antarctica has long been a world apart. In the 19th and early 20th centuries, when dedicated expeditions began, explorers were cut off from home for years at a time, reliant on ships sailing back and forth from civilization to carry physical mail. They were utterly alone, the only humans for thousands of miles.

This made things difficult, emotionally and physically. With only the supplies they had on hand, explorers were limited in the scientific experiments they could conduct. They couldn’t send an SOS if they needed help (which was fairly often). And also—importantly, because many relied on publicity for funding—they couldn’t let the world know what was going on.

In 1911, an Australian expedition led by Douglas Mawson was the first to take an antenna to the continent and attempt to transmit and receive wireless signals. But while Mawson was able to send a few messages during the team’s first season, he never received any back, so he didn’t know if his had been successful.

The winds at their base at Cape Denison, on the Antarctic coast directly south of Australia, raged at 70 kilometers an hour—every day, every night, for months on end. They finally succeeded in raising the mast during their second winter, only to be faced with a different problem: their radio operator was unable to work, having suffered psychosis during the six months of darkness. So the expedition was left isolated again.

While Antarctic telecommunications have been steadily improving ever since the first permanent bases were established, many decades after Mawson’s ill-fated trip, life on the ice has always been characterized by some level of disconnection. And as life at home has become ever more dependent on constant connection, instant updates, streaming, and algorithms, living in Antarctica has been seen as a break—for better and for worse—from all the digital hustle-bustle.

But the end of that long-standing disparity is now in sight. Starlink, the satellite constellation developed by Elon Musk’s company SpaceX to service the world with high-speed broadband internet, has come to Antarctica, finally bringing with it the sort of connectivity enjoyed by the world beyond the ice.

Mawson and sledge Adelie
Douglas Mawson and his team had difficulty
raising a radio antenna during the expedition
they embarked on in 1911.
 a ticker tape parade for Admiral Byrd returning from Antartica in New York CityRead More

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By: Allegra Rosenberg
Title: How Antarctica’s history of isolation is ending—thanks to Starlink
Sourced From: www.technologyreview.com/2024/02/26/1088144/antarctica-starlink-elon-musk-satellite-internet/
Published Date: Mon, 26 Feb 2024 10:00:00 +0000

Did you miss our previous article…
https://mansbrand.com/trump-wants-to-unravel-bidens-landmark-climate-law-here-is-whats-most-at-risk/

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Trump wants to unravel Biden’s landmark climate law. Here is what’s most at risk.

GettyImages 1853587512 crop scaled

President Joe Biden’s crowning legislative achievement was enacting the Inflation Reduction Act, easily the nation’s largest investment into addressing the rising dangers of climate change.

Yet Donald Trump’s advisors and associates have clearly indicated that dismantling the landmark law would sit at the top of the Republican front-runner’s to-do list should he win the presidential election. If he succeeds, it could stall the nation’s shift to cleaner industries and stunt efforts to cut the greenhouse-gas pollution warming the planet.

The IRA unleashes at least hundreds of billions of dollars in federal subsidies for renewable energy sources, electric vehicles, batteries, heat pumps, and more. It is the “backbone” of the Biden administration’s plan to meet the nation’s commitments under the Paris climate agreement, putting the US on track to cut emissions by as much as 42% from 2005 levels by the end of this decade, according to the Rhodium Group, a research firm. 

But the sprawling federal policy package marks the “biggest defeat” conservatives have suffered during Biden’s tenure, according to Myron Ebell, who led the Environmental Protection Agency transition team during Trump’s administration. And repealing the law has become an obsession among many conservatives, including the authors of the Heritage Foundation’s Project 2025, widely seen as a far-right road map for the early days of a second Trump administration.

The IRA’s tax credits for EVs and clean power projects appear especially vulnerable, climate policy experts say. Losing those provisions alone could reshape the nation’s emissions trajectory, potentially adding back hundreds of millions of metric tons of climate pollution this decade.

Moreover, Trump’s wide-ranging pledges to weaken international institutions, inflame global trade wars, and throw open the nation’s resources to fossil-fuel extraction could have compounding effects on any changes to the IRA, potentially undermining economic growth, the broader investment climate, and prospects for emerging green industries.

Farewell to EV tax credits

The IRA leverages government funds to accelerate the energy transition through a combination of direct grants and tax credits, which allow companies or individuals to cut their federal obligations in exchange for buying, installing, investing in, or producing cleaner power and products. It is enacted law, not a federal agency regulation or executive order, which means that any substantial changes would need to be achieved through Congress.

But the tax cuts for individuals pushed through during Trump’s time in office are set to expire next year. If he wins a second term, legislators seeking to extend those cuts could crack up the tax code and excise key components of the IRA, particularly if Republicans retain control of the House and pick up seats in the Senate. Eliminating any of those tax credits could help offset the added cost of restoring those Trump-era benefits.

Numerous policy observers believe that the pair of EV tax credits in the IRA, which together lop $7,500 off the cost of electric cars and trucks, would be one of the top targets. Subsidizing the cost of EVs polls terribly among Republicans, and throughout the primaries, most of the party’s candidates for president have fiercely attacked government support for the vehicles—none more than Trump himself. 

Close up of former President Trump pointing directly at camera while speaking at a campaign event in Iowa
Former President Donald Trump speaks at a campaign event in Iowa.SCOTT OLSON/GETTY IMAGES

On the campaign trail, he has repeatedly, erroneously referred to the policy as a mandate rather than a subsidy, while geographically tailoring the critique to his audience.

At a December rally in Iowa, the nation’s biggest corn producer, he pledged to cancel “Crooked Joe Biden’s insane, ethanol-killing electric-vehicle mandate on day one.”

And in the battleground state of Michigan in September, he pandered to the fears of autoworkers.

“Crooked Joe is siding

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By: James Temple
Title: Trump wants to unravel Biden’s landmark climate law. Here is what’s most at risk.
Sourced From: www.technologyreview.com/2024/02/26/1088921/trump-wants-to-unravel-bidens-landmark-climate-law-here-is-whats-most-at-risk/
Published Date: Mon, 26 Feb 2024 10:00:00 +0000

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The Download: Trump’s potential climate impact, and the end of cheap helium

This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Trump wants to unravel Biden’s landmark climate law. Here is what’s most at risk.

President Joe Biden’s crowning legislative achievement was enacting the Inflation Reduction Act, easily the nation’s largest investment into addressing the rising dangers of climate change.

Yet Donald Trump’s advisors and associates have clearly indicated that dismantling the landmark law would sit at the top of the Republican front-runner’s to-do list should he win the presidential election.

If he succeeds, it could stall the nation’s shift to cleaner industries and stunt efforts to cut the greenhouse-gas pollution warming the planet. The IRA’s tax credits for EVs and clean power projects appear especially vulnerable. But lots of other provisions could also come under attack. Read the full story.

—James Temple

The era of cheap helium is over—and that’s already causing problems

Helium is excellent at conducting heat. And at temperatures close to absolute zero, at which most other materials would freeze solid, helium remains a liquid. That makes it a perfect refrigerant for anything that must be kept very cold.

Liquid helium is therefore essential to any technology that uses superconducting magnets, including MRI scanners and some fusion reactors. Helium also cools particle accelerators, quantum computers, and the infrared detectors on the James Webb Space Telescope.

“It’s a critical element for the future,” says Richard Clarke, a UK-based helium resources consultant. However, it’s also played a critical role throughout the history of technology development, while remaining in tight supply.

As part of MIT Technology Review’s 125th anniversary series, we looked back at our coverage of how helium became such an important resource, and considered how demand might change in the future. Read the full story.

—Amy Nordrum

How Antarctica’s history of isolation is ending—thanks to Starlink

“This is one of the least visited places on planet Earth and I got to open the door,” Matty Jordan, a construction specialist at New Zealand’s Scott Base in Antarctica, wrote in the caption to the video he posted to Instagram and TikTok in October 2023.

In the video, he guides viewers through the hut, pointing out where the men of Ernest Shackleton’s 1907 expedition lived and worked.

The video has racked up millions of views from all over the world. It’s also kind of a miracle: until very recently, those who lived and worked on Antarctic bases had no hope of communicating so readily with the outside world.

That’s starting to change, thanks to Starlink, the satellite constellation developed by Elon Musk’s company SpaceX to service the world with high-speed broadband internet. Read the full story.

—Allegra Rosenberg

Wikimedia’s CTO: In the age of AI, human contributors still matter

Selena Deckelmann is the chief product and technology officer at the Wikimedia Foundation, the nonprofit that hosts and manages Wikipedia.

There she not only guides one of the most turned-to sources of information in the world but serves a vast community of “Wikipedians,” the hundreds of thousands of real-life individuals who spend their free time writing, editing, and discussing entries—in more than 300 languages—to make Wikipedia what it is today.

It is undeniable that technological advances and cultural shifts have transformed our online universe over the years—especially with the recent surge in AI-generated content—but Deckelmann still isn’t afraid of people on the internet. She believes they are its future. Read the full story.

—Rebecca Ackermann

The two stories above are from the next issue of MIT Technology Review, all about hidden worlds. It’s set to go live on Wednesday—subscribe now to get your copy!

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 The Supreme Court will decide whether states can control social media
It’ll start hearing arguments today about whether laws aimed at controlling online platforms in Texas and Florida are constitutional. (WP $)
Here’s what you need to know. (NYT $)
Texas’s law is dangerous. Striking it down could be even worse. (The Atlantic $)

2 Celebrities are being ‘deepfaked’ for adverts
AI-generated videos have them endorsing and promoting things they’ve never even heard of. (BBC)
These companies show why the next AI wave won’t revolve around chatbots. (Fast Company)

3 Inside TikTok’s live money-making machine
Live streaming can be hugely lucrative—for both the creator and TikTok

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By: Charlotte Jee
Title: The Download: Trump’s potential climate impact, and the end of cheap helium
Sourced From: www.technologyreview.com/2024/02/26/1088958/climate-impact-trump-cheap-helium/
Published Date: Mon, 26 Feb 2024 13:12:00 +0000

Did you miss our previous article…
https://mansbrand.com/meet-the-divers-trying-to-figure-out-how-deep-humans-can-go/

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