A few years ago, a young man from California’s technology scene began popping up in the world’s leading developmental biology labs. These labs were deciphering the secrets of embryos and had a particular interest in how eggs are formed. Some thought if they discovered that recipe, they would be able to copy it and transmute any cell into an egg.
Their visitor, Matt Krisiloff, said he wanted to help. Krisiloff didn’t know any biology, and he was only 26. But after leading a research program at Y Combinator, the famous startup incubator in San Francisco that was an early funder of such companies as Airbnb and Dropbox, he said, he was “well connected,” with access to wealthy tech investors.
Krisiloff also had a specific interest in the artificial-egg technology. He’s gay, and he knew that theoretically, a cell from a man could be turned into an egg. If that were ever possible, two men could have a child that was genetically related to both. “I was interested in the idea of ‘When can same-sex couples have children together?’” says Krisiloff. “I thought that this was the promising technology for doing this.”
Today the company Krisiloff started, called Conception, is the largest commercial venture pursuing what’s called in vitro gametogenesis, which refers turning adult cells into gametes—sperm or egg cells. It employs around 16 scientists and has raised $20 million from well-known tech figures including Sam Altman, the CEO of OpenAI and former president of Y Combinator; Jaan Tallinn, one of the founders of Skype; and Blake Borgeson, a cofounder of Recursion Pharmaceuticals.
The company is initially trying to make replacement eggs for women. That’s scientifically easier than making eggs from male cells, and it has an obvious market. People are having kids later in life, but a woman’s supply of healthy eggs nosedives in her 30s. It’s a major reason patients visit IVF clinics.
Conception is starting with blood cells from female donors and trying to transform these into the first “proof-of-concept human egg” made in the lab. The company hasn’t done it yet—nor has anyone else. There are still scientific puzzles to overcome, but Krisiloff sent out an email to supporters earlier this year saying his startup might be be “the first in the world to accomplish this goal in the not-too-distant future.” It says that artificial eggs “could become one of the most important technologies ever created.”
That’s no exaggeration. If scientists can generate supplies of eggs, it would break the rules of reproduction as we know them. Women without ovaries—for example, because of cancer or surgery—might be able to have biologically related children. What’s more, lab-made eggs would cancel the age limits on female fertility, allowing women to have related babies at 50, 60, or even beyond.
The prospect of egg cells from a blood draw is profound—and ethically fraught. Conception’s process for making eggs from stem cells has required human fetal tissue. And if reproduction is dissociated from what have been the accepted facts of life, unfamiliar scenarios could result. It opens the door not only for same sex-reproduction, but perhaps even for one individual—or four—to generate an offspring.
More realistically, because the technology could turn eggs into a manufactured resource, it could supercharge the path to designer children. If doctors can make a thousand eggs for a patient, they’ll also be able to fertilize all of them and test to find the best resulting embryos, scoring their genes for future health or intelligence. Such a laboratory process would also permit unfettered genetic editing with DNA engineering tools such as CRISPR. As Conception put it in a pitch sent out earlier this year, the company anticipates that artificial eggs could allow “wide-scale genomic selection and editing in embryos.”
Says Krisiloff: “If you could meaningfully select against Parkinson’s risk, Alzheimer’s risk, I think this then becomes very desirable.” The potential commercial and health payoffs could be huge.
For scientific reasons, turning a man’s cell into a healthy egg is expected to be harder, and Conception hasn’t even tried
By: Antonio Regalado
Title: How Silicon Valley hatched a plan to turn blood into human eggs
Sourced From: www.technologyreview.com/2021/10/28/1038172/conception-eggs-reproduction-vitro-gametogenesis/
Published Date: Thu, 28 Oct 2021 12:40:00 +0000
LATAM crypto exchange Bitso and FMF launch NFT of Mexico’s National Team jerseys
Bitso, a leading cryptocurrency platform operating in Latin America, and the Mexican Football Federation (FMF), today announced the joint launch of the first collectible NFT of the Mexico National Team’s jerseys that was acquired in cryptocurrencies.
This morning through their social media platforms, the FMF and Bitso announced the opportunity to acquire the new official National Team fan jerseys ahead of the team’s participation in the 2022 World Cup. In just 20 minutes, the entire collection sold out.
The NFTs of the jerseys have an exclusive design for the metaverse – each is unique on the blockchain and can be resold by its owner in subsequent transactions.
The collection consisted of 100 official physical jerseys, each with a corresponding NFT version of the jersey that fans’ avatars can wear within the Decentraland metaverse. Each physical and NFT jersey set sold for the equivalent of $1,800 MXN in ethers.
“Our mission is to make cryptocurrency useful in the everyday life of Mexicans; we are committed to spreading the technology through innovative opportunities that help people throughout the country familiarize themselves with this new world. We are very excited to offer the incredible, historic opportunity for the fans of our National Team so that through their Bitso account, they can wear the colors of the National Team on and ‘off’ the field in the metaverse.”
– Bárbara González Briseño, General Director of Bitso México
Created by Bitso, the virtual jersey sports the official colors of Mexico and the new National Team shield, characteristics that will make it stand out when users wear it in the virtual world of Decentraland.
The post LATAM crypto exchange Bitso and FMF launch NFT of Mexico’s National Team jerseys appeared first on CryptoNinjas.
Title: LATAM crypto exchange Bitso and FMF launch NFT of Mexico’s National Team jerseys
Sourced From: www.cryptoninjas.net/2022/07/29/latam-crypto-exchange-bitso-and-fmf-launch-nft-of-mexicos-national-team-jerseys/
Published Date: Fri, 29 Jul 2022 15:19:02 +0000
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Long-running crypto exchange EXMO unveils “lively” rebrand amidst growth
EXMO, a crypto exchange platform operating since 2014, announced this week a rebranded visual identity with includes a new logo, brand colors, and design features. This new branding comes as EXMO continues to grow its crypto platform while also seeking to expand its presence in other jurisdictions.
Some new developments underway at EXMO:
Soon, users will be able to earn passive income from EXMO’s new staking platform.Plans to launch an EXMO crypto debit card.Expansion of its services in international markets with the opening of offices in Poland and Lithuania.
EXMO’s new logo
The rationale for the re-brand:
“At EXMO, we have a vision of a world where crypto is in every wallet. Hassle-free. We want to achieve this by making crypto as simple and accessible to everyone as possible. And we know that you already appreciate EXMO for offering user-friendly services and helpful support. Also for the opportunity to trade anywhere and anytime, closing deals in just a few taps. Such important changes required a rethinking of our corporate style, which has long needed a massive upgrade. So today we are introducing a new brand identity for EXMO with a completely new visual concept. We are launching a new logo, brand colors, and design elements. Our key design principles are simplicity, boldness, and a pinch of fun. But most importantly, we have changed our logo. Simple and easily recognizable, it represents the humanity of our brand. The logo stands out due to the wavy letter ‘m’ which symbolizes exchange rate charts and also resembles a spring that will launch you into the crypto world.”
– The EXMO Team regarding the re-branding
The post Long-running crypto exchange EXMO unveils “lively” rebrand amidst growth appeared first on CryptoNinjas.
Title: Long-running crypto exchange EXMO unveils “lively” rebrand amidst growth
Sourced From: www.cryptoninjas.net/2022/07/26/long-running-crypto-exchange-exmo-unveils-lively-rebrand-amidst-growth/
Published Date: Tue, 26 Jul 2022 08:10:38 +0000
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Stitching together the grid will save lives as extreme weather worsens
The blistering heat waves that set temperature records across much of the US in recent days have strained electricity systems, threatening to knock out power in vulnerable regions of the country.
The electricity has largely stayed online so far this summer, but there have been scattered problems and close calls already.
Heavy use of energy-sucking air-conditioners is the biggest problem. But intense heat can also reduce the output of power plants, blow transformers, and force power lines to sag. Severe droughts across large parts of the country have also significantly reduced the availability of hydroelectric power, according to the North American Electric Reliability Corporation (NERC).
It’s unlikely to get better soon. A number of grid operators may struggle to meet peak summer demand, creating the risk of rolling blackouts, the NERC report notes.
The nation’s isolated and antiquated grids are in desperate need of upgrades to keep the lights, heat, and air-conditioning on in the midst of extreme weather events that climate change is making more common, severe, and dangerous. One clear way to ease many of these issues is to more tightly integrate the country’s regional grids, stitching them together with more long-range transmission lines.
If electricity generated in one area can be more easily shared across much wider regions, power can simply flow to where it’s needed at those moments when customers crank up air-conditioners en masse, or when power plants or fuel supply lines fail amid soaring temperatures, wildfires, hurricanes, or other events, says Liza Reed, a research manager focused on transmission at the Niskanen Center, a Washington, DC, think tank.
The problem is it’s proved difficult to build more long-range transmission and grid interconnections for a variety of reasons, including the permitting challenges of erecting wires through private and public lands across cities, counties, and states and the reluctance of local authorities to forfeit control or submit to greater federal oversight.
The case of Texas
The unreliability of the US grid is not a new problem. Severe heat and winter storms have repeatedly exposed the frailty of electricity systems in recent years, leaving thousands to millions of people without power as temperatures spiked or plunged.
One of the fundamental challenges is that the grids today are highly fragmented. There are three main electricity networks within the US: the Eastern Grid, the Western Grid, and the Electric Reliability Council of Texas (ERCOT). But there are numerous regional transmission organizations within those first two systems, including the California Independent System Operator, Southwest Power Pool, PJM Interconnection, New York ISO, and more.
These grids form a complex web of networks operating under different regulators, rules and market structures, and often with limited connections between them.
A variety of regional transmission organizations oversee different parts of the nation’s aging and fragmented grids, which operate under different rules and with often limited connections between them.
ERCOT is especially isolated, in part because of the desire among local politicians, citizens, and power companies to avoid added competition, the hassle of following other states’ rules, and oversight from the Federal Energy Regulatory Commission (FERC). But the state offers a case study in why that can be a serious problem amid increasingly harsh climate conditions, Reed says.
The Texas grid operator pleaded with customers several times earlier this month to cut electricity use as blistering summer temperatures created demand surges that threatened to outstrip supply and require rolling blackouts. Low wind conditions, cloud cover, and outages at fossil-fuel power plants added to the strains.
Shutting off the electricity needed to run air-conditioning in triple-digit temperatures
By: James Temple
Title: Stitching together the grid will save lives as extreme weather worsens
Sourced From: www.technologyreview.com/2022/07/28/1056483/stitching-together-the-grid-will-save-lives-as-extreme-weather-worsens/
Published Date: Thu, 28 Jul 2022 08:00:00 +0000
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