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37 trillion. That is the number or cells that form a human being. How they all work together to sustain life is possibly the biggest unsolved puzzle in biology. A group of up-and-coming technologies for spatially resolved multi omics, here collectively called “spatial omics,” may provide researchers with the solution.

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Over the last 20 years, the omics revolution has enabled us to understand cell and tissue biology at ever increasing resolutions. Bulk sequencing techniques that emerged in the mid 2000s allowed the study of mixed populations of cells. A decade later, single-cell omics methods became commercially available, revolutionizing our understanding of cell physiology and pathology. These methods, however, required dissociating cells from their tissue of origin, making it impossible to study their spatial organization in tissue.

Spatial omics refers to the ability to measure the activity of biomolecules (RNA, DNA, proteins, and other omics) in situ—directly from tissue samples. This is important because many biological processes are controlled by highly localized interactions between cells that take place in spatially heterogeneous tissue environments. Spatial omics allows previously unobservable cellular organization and biological events to be viewed in unprecedented detail.

A few years ago, these technologies were just prototypes in a handful of labs around the world. They worked only on frozen tissue and they required impractically large amounts of precious tissue biopsies. But as these challenges have been overcome and the technologies commercialized by life science technology providers, these tools have become available to the wider scientific community. Spatial omics technologies are now improving at a rapid pace, increasing the number of biomolecules that can be profiled from hundreds to tens of thousands, while increasing resolution to single-cell and even subcellular scales.

Complementary advances in data and AI will expand the impact of spatial omics on life sciences and health care—while also raising new questions. How are we going to generate the large datasets that are necessary to make clinically relevant discoveries? What will data scientists see in spatial omics data through the lens of AI?

Discovery requires large-scale spatial omics datasets

Several areas of life science are already benefiting from discoveries made possible by spatial omics, with the biggest impacts in cancer and neurodegenerative disease research. However, spatial omics technologies are very new, and experiments are challenging and costly to execute. Most present studies are performed by single institutions and include only a few dozen patients. Complex cell interactions are highly patient-specific, and they cannot be fully understood from these small cohorts. Researchers need the data to enable hypothesis generation and discovery.

This requires a shift in mentality toward collaborative projects, which can generate large-scale reference datasets both on healthy organs and human diseases. Initiatives such as The Cancer Genome Atlas (TCGA) have transformed our understanding of cancer. Similar large-scale spatial omics efforts are needed to systematically interrogate the role of spatial organization in healthy and diseased tissues; they will generate large datasets to fuel many discovery programs. In addition, collaborative initiatives steer further improvement of spatial omics technologies, generate data standards and infrastructures for data repositories, and drive the development and adoption of computational tools and algorithms.

At Owkin we are pioneering the generation of such datasets. In June 2023, we launched an initiative to create the world largest spatial omics dataset in cancer, with a vision to include data from 7,000 patients with seven difficult-to-treat cancers. The project, known as MOSAIC (Multi-Omics Spatial Atlas in Cancer), won’t stop at the data generation, but will mine the data to learn disease biology and identify new molecular targets against which to design new drugs.

Owkin is well placed to drive this kind of initiative. We can tap a vast network of collaborating hospitals across the globe: to create the MOSAIC dataset, we are working with five world-class cancer research hospitals. And we have deep experience in AI: In the last five

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By: Eric Y. Durand, PhD
Title: Mapping the micro and macro of biology with spatial omics and AI
Sourced From: www.technologyreview.com/2023/12/12/1084492/mapping-the-micro-and-macro-of-biology-with-spatial-omics-and-ai/
Published Date: Tue, 12 Dec 2023 15:30:00 +0000

Tech

Top 5 Bitcoin ATM Locations in Athens for Fast and Easy Crypto Access

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As a crypto analyst and frequent investor in the Greek digital currency market, I can confidently recommend Bcash for convenient and secure Bitcoin purchasing in Athens. With 10 strategically located crypto ATM hotspots spanning central Athens and the northern suburbs, Bcash enables instant access to leading cryptocurrencies like BTC, ETH, and USDT.

Experience the Leading Greek Crypto ATM Network at Bcash’s Hotspots

From first-hand experience, I’m impressed by Bcash’s easy user interface, excellent customer assistance, and fair prices. Their two-way ATM machines allow both buying with Euro cash and selling crypto for instant fiat payouts. I found the simple on-screen instructions enabled completing transactions in under 2 minutes!

Bcash’s Bitcoin ATM network stands out from competitors by aligning prices closely with real-time crypto market rates. Their typical 6-8% fees are much cheaper than traditional crypto brokers and exchanges in Greece. For investors seeking reliable local crypto access, Bcash has the solutions.

Central Athens Bcash Shops Offer Prime Buying and Selling

For maximum security while buying or selling Bitcoin, Bcash’s dedicated Athens shop locations are ideal. Their main office on Dimitrakopoulou Street in the city center contains a premier crypto ATM location open 6 days weekly. It’s close to public transit for easy access.

I also frequented Bcash’s Glyfada branch in the south shopping district. With spacious storefront access and long business hours, this hotspot proved one of my favorite crypto transaction destinations. The expert staff helped guide my buying process as a beginner too.

Glyfada Shopping District ATM Location

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The Glyfada store sits right on Gennimata Street, providing a safe and high-traffic venue for easily buying and selling leading cryptocurrencies. Open Monday through Saturday, this major Bcash outlet enjoys strong local area visibility for crypto investors.

Northern Suburbs ATM Hotspots

In Athens’ northern suburbs, I purchased Bitcoin multiple times at Bcash’s Nea Erythraia shop off Mikras Asias Street. Located just 20 minutes from the city center, it makes crypto conveniently accessible for residents across northeast Athens.

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Piraeus Port Shopping District ATM

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While recently docking overnight at the Piraeus cruise port as part of an Aegean island-hopping vacation, I encountered one of Bcash’s handy crypto ATMs just 5 minutes from the passenger terminals. Located right on Sachtouri Street inside the company’s Piraeus store, this machine proved hugely convenient for buying Bitcoin during my stay.

As one of Europe’s largest passenger ports, Piraeus receives over 4 million travelers every year who could benefit from easy access to crypto. Whether before boarding ferries to venture deeper into the Greek islands or arriving back onshore in Athens, the Bcash outlet enables obtaining coins to capture optimal valuations.

And for tourists exploring downtown Piraeus’ vast harborfront retail area, having a trusted Bitcoin ATM one block away gives peace of mind. Rather than relying solely on airport kiosks, cruise ship visitors can turn Euros into crypto almost anytime thanks to Bcash’s strategic positioning. As vacationing investors, that accessibility offers real advantages.

Bcash Brings Bitcoin to the Greek Islands

Rhodes Island BTM Location

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By: CryptoNinjas.net
Title: Top 5 Bitcoin ATM Locations in Athens for Fast and Easy Crypto Access
Sourced From: www.cryptoninjas.net/2024/03/03/top-5-bitcoin-atm-locations-in-athens-for-fast-and-easy-crypto-access/
Published Date: Sun, 03 Mar 2024 17:18:46 +0000

Did you miss our previous article…
https://mansbrand.com/the-citizen-scientists-chronicling-a-neglected-but-vital-mexican-river/

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The citizen scientists chronicling a neglected but vital Mexican river

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The city of Monterrey in northeastern Mexico is an industrial powerhouse that has rapidly devoured green space to make room for its 5.3 million people. The Sierra Madre Oriental mountain range around the city is still holding strong, though the hills are increasingly encroached on by the urban sprawl of skyscrapers, apartment buildings, industrial parks, and highways. The same can’t be said for the Río Santa Catarina, the river that has been the vital core of the city for hundreds of years.

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Lizbeth Ovalle, founder of Viaje al Microcosmos, gathers water from
the Río Santa CatarinaANDREA VILLARREAL
circle of approx 25 people seated on the rocky shore of a river
Participants in one of the Viaje al Microcosmos river walks sit to share their observations and reflect on their findings.
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Andrea Villarreal, a member of the citizen science group, shows a participant how to use the iNaturalist app, which can help identify plants and animals.

overgrowth in the area below an overpass
Viaje al Micrososmos
organized a walk along this stretch of the Río Santa Catarina in October 2023.LORENA RíOS

Today, the Río Santa Catarina looks more like a forest than a river. It is mostly a dry jumble of rocks whose water is diverted to supply the city’s growing needs. Much of the riverbed is obscured by vegetation that has grown wild since a hurricane in 2010 destroyed many structures along the river, including soccer fields, parking lots, and a mini-golf course. But despite what many city officials and residents make of it, this urban river is very much alive, and a group of young women wants to prove it.

The group, called Viaje al Microcosmos de Nuevo LeónJourney into the Microcosm of Nuevo León), is not made up of scientists but, rather, of concerned citizens. Through the use of art and citizen science, its members are documenting and sharing with others the river’s forgotten nature—its trees, bushes, birds, flowers, insects, and even microorganisms (from which the group takes its name).

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By: Lorena Ríos
Title: The citizen scientists chronicling a neglected but vital Mexican river
Sourced From: www.technologyreview.com/2024/02/28/1088234/monterrey-mexico-rio-santa-catarina-viaje-al-microcosmos/
Published Date: Wed, 28 Feb 2024 10:00:00 +0000

Did you miss our previous article…
https://mansbrand.com/what-luddites-can-teach-us-about-resisting-an-automated-future/

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What Luddites can teach us about resisting an automated future

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A story in comic format. In this first panel, two figures in silhouette look out at a modern city skyline.  The text reads,

A person's smiling headshot being uploaded.  The text reads,

The headshot from the previous panel with distroted features and a wavy new background. The text reads,

Two people look at the blank space where the framed picture of a flower has been stolen by a giant robot hand. The text reads,

Two panels. In the first, a scrabbly line resembling a signature. The text reads,

The text reads,

Text across the top continues, Read More

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By: Tom Humberstone
Title: What Luddites can teach us about resisting an automated future
Sourced From: www.technologyreview.com/2024/02/28/1088262/luddites-resisting-automated-future-technology/
Published Date: Wed, 28 Feb 2024 10:00:00 +0000

Did you miss our previous article…
https://mansbrand.com/the-worlds-most-famous-concert-pianos-got-a-major-tech-upgrade/

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