Connect with us

This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

A wave of drugs dreamed up by AI is on its way

Alex Zhavoronkov has been messing around with artificial intelligence for more than a decade. In 2016, the programmer and physicist was using AI to rank people by looks and sort through pictures of cats.

Now he says his company, Insilico Medicine, has created the first “true AI drug” that’s advanced to a test of whether it can cure a fatal lung condition in humans.

Popular forms of AI can draw pictures and answer questions. But there’s a growing effort to get AI to dream up cures for awful diseases, too. The problem they are solving, however, is an old one. Read the full story.

—Antonio Regalado

Google DeepMind’s new AI assistant helps elite soccer coaches get even better

The news: Soccer teams are always looking to get an edge over their rivals. They might want to add a new AI assistant developed by Google DeepMind to their arsenal. It can suggest tactics for soccer set-pieces that are even better than those created by professional club coaches.

How it works: The system, called TacticAI, works by analyzing a dataset of 7,176 corner kicks taken by players for Liverpool FC, one of the biggest soccer clubs in the world. It uses predictive and generative AI models to analyze each scenario and produce recommendations and predictive outcomes. Read the full story.

—Rhiannon Williams

Chinese platforms are cracking down on influencers selling AI lessons

Over the last year, a few Chinese influencers have made millions of dollars peddling short video lessons on AI, profiting off people’s fears about the as-yet-unclear impact of the new technology on their livelihoods.

But the platforms they thrived on have started to turn against them. Just a few weeks ago, WeChat and Douyin began suspending, removing, or restricting their accounts. While influencers on these platforms have been turning people’s anxiety into traffic and profits for a long time, the latest actions show how Chinese social platforms are trying to contain the damage before it goes too far. Read the full story.

—Zeyi Yang

This story is from China Report, our weekly newsletter giving you the inside track on all things happening in China. Sign up to receive it in your inbox every Tuesday.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 DeepMind co-founder Mustafa Suleyman is joining Microsoft 
He’ll head up the company’s consumer arm, developing AI-infused products. (Bloomberg $)
Suleyman will leave his startup, Inflection AI, along with a load of its staff. (NYT $)
Inflection’s investors won’t be left out of pocket, though. (The Information $)
Check out our interview with Suleyman about why he thinks generative AI is just a phase. (MIT Technology Review)

2 China is sending a satellite to the dark side of the moon
It’ll play a crucial role in the country’s bid to leapfrog the US in moon exploration. (Reuters)
Some scientists aren’t sure if exploring Mars is a wise investment. (Undark Magazine)

3 Anonymous career site Glassdoor exposed its users’ real names
Which, unsurprisingly, has upset users who posted honest reviews of their former workplaces. (Ars Technica)

4 The concrete industry has a major carbon problem
Now, emission-capturing formulas could make a difference. (Wired $)
The climate solution beneath your feet. (MIT Technology Review)

5 Artists who use AI are more productive
But, crucially, they’re less original. (New Scientist $)
This artist is dominating AI-generated art. And he’s not happy about it. (MIT Technology Review)

6 Saudi Arabia is poised to become an AI superpower
To the tune of a $40 billion sinking fund. (NYT $)
We’re just five years away from artificial general intelligence, according to Nvidia CEO Jensen Huang, at least. (TechCrunch)
Google DeepMind wants to define what counts as artificial general intelligence. (MIT Technology Review)

7 Brace yourself—dynamic pricing is coming
Emboldened by Uber’s surge pricing model, other businesses want in. (Vox)

8 Indonesia’s ebike shops are dicing with danger 
They’re creating souped-up batteries that prioritize power over safety. (Rest of World)
Three things to love about batteries. (MIT Technology Review)

9 Did you just poke me on Facebook?
👉
The social network has quietly restored one of its weirdest features. (Insider $)

10 This unknown Swedish composer has racked up more Spotify plays than ABBA
Johan Röhr is the

Read More

————

By: Rhiannon Williams
Title: The Download: AI drugs, and how AI is improving soccer tactics
Sourced From: www.technologyreview.com/2024/03/20/1089956/the-download-ai-drugs-and-how-ai-is-improving-soccer-tactics/
Published Date: Wed, 20 Mar 2024 13:10:00 +0000

Continue Reading

Tech

Meet the architect creating wood structures that shape themselves

ICD ITKE HygroShell2022 P01a scaled

Humanity has long sought to tame wood into something more predictable. Sawmills manufacture lumber from trees selected for consistency. Wood is then sawed into standard sizes and dried in kilns to prevent twisting, cupping, or cracking. Generations of craftsmen have employed sophisticated techniques like dovetail joinery, breadboard ends, and pocket flooring to keep wood from distorting in their finished pieces.

But wood is inherently imprecise. Its grain reverses and swirls. Trauma and disease manifest in scars and knots.

Instead of viewing these natural tendencies as liabilities, Achim Menges, an architect and professor at the University of Stuttgart in Germany, sees them as wood’s greatest assets. Menges and his team at the Institute for Computational Design and Construction are uncovering new ways to build with the material by using computational design—which relies on algorithms and data to simulate and predict how wood will behave within a structure long before it is built. He hopes this work will enable architects to create more sustainable and affordable timber buildings by reducing the amount of wood required.

Menges’s recent work has focused on creating “self-shaping” timber structures like the HygroShell, which debuted at the Chicago Architecture Biennial in 2023. Constructed from prefabricated panels of a common building material known as cross-laminated timber, HygroShell morphed over a span of five days, unfurling into a series of interlaced sheets clad with wooden scale-like shingles that stretched to cover the structure as it expanded. Its final form, designed as a proof of concept, is a delicately arched canopy that rises to nearly 33 feet (10 meters) but is only an inch thick. In a time-lapse video, the evolving structure resembles a bird stretching its wings.

HygroShell takes its name from hygroscopicity, a property of wood that causes it to absorb or lose moisture with humidity changes. As the material dries, it contracts and tends to twist and curve. Traditionally, lumber manufacturers have sought to minimize these movements. But through computational design, Menges’s team can predict the changes and structure the material to guide it into the shape they want.

“From the start, I was motivated to understand computation not as something that divides the physical and the digital world but, instead, that deeply connects them.”

Achim Menges, architect and professor, University of Stuttgart in Germany

The result is a predictable and repeatable process that creates tighter curves with less material than what can be attained through traditional construction techniques. Existing curved structures made from cross-laminated timber (also known as mass timber) are limited to custom applications and carry premium prices, Menges says. Self-shaping, in contrast, could offer industrial-scale production of curved mass timber structures for far less cost.

To build HygroShell, the team created digital profiles of hundreds of freshly sawed boards using data about moisture content, grain orientation, and more. Those parameters were fed into modeling software that predicted how the boards were likely to distort as they dried and simulated how to arrange them to achieve the desired structure. Then the team used robotic milling machines to create the joints that held the panels together as the piece unfolded.

“What we’re trying to do is develop design methods that are so sophisticated they meet or match the sophistication of the material we deal with,” Menges says.

Menges views “self-shaping,” as he calls his technique, as a low-energy way of creating complex curved architectures that would otherwise be too difficult to build on most construction sites. Typically, making curves requires extensive machining and a lot more materials, at considerable cost. By letting the wood’s natural properties do the heavy lifting, and using robotic machinery to prefabricate the structures, Menges’s process allows for thin-walled timber construction that saves material and money.

Read More

————

By: John Wiegand
Title: Meet the architect creating wood structures that shape themselves
Sourced From: www.technologyreview.com/2024/06/24/1093513/achim-menges-architect-wood-buildings-sustainability/
Published Date: Mon, 24 Jun 2024 09:00:00 +0000

Continue Reading

Tech

The Download: hyperrealistic deepfakes, and using math to shape wood

This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Synthesia’s hyperrealistic deepfakes will soon have full bodies

Startup Synthesia’s AI-generated avatars are getting an update to make them even more realistic: They will soon have bodies that can move, and hands that gesticulate.

The new full-body avatars will be able to do things like sing and brandish a microphone while dancing, or move from behind a desk and walk across a room. They will be able to express more complex emotions than previously possible, like excitement, fear, or nervousness.

These new capabilities, which are set to launch toward the end of the year, will add a lot to the illusion of realism. That’s a scary prospect at a time when deepfakes and online misinformation are proliferating. Read the full story and watch our reporter’s avatars meet each other.

—Melissa Heikkilä

Meet the architect creating wood structures that shape themselves

Humanity has long sought to tame wood into something more predictable, but it is inherently imprecise. Its grain reverses and swirls. Trauma and disease manifest in scars and knots.

Instead of viewing these natural tendencies as liabilities, Achim Menges, an architect and professor at the University of Stuttgart in Germany, sees them as wood’s greatest assets.

Menges and his team at the Institute for Computational Design and Construction are uncovering new ways to build with wood by using algorithms and data to simulate and predict how wood will behave within a structure long before it is built. He hopes this will help create more sustainable and affordable timber buildings by reducing the amount of wood required. Read our story all about him and his work.

—John Wiegand

This story is from the forthcoming print issue of MIT Technology Review, which explores the theme of Play. It’s set to go live on Wednesday June 26, so if you don’t already, subscribe now to get a copy when it lands.

Live: How generative AI could transform games

Generative AI could soon revolutionize how we play video games, creating characters that can converse with you freely, and experiences that are infinitely detailed, twisting and changing every time you experience them.

Together, these could open the door to entirely new kinds of in-game interactions that are open-ended, creative, and unexpected. One day, the games we love playing may not have to end. Read our executive editor Niall Firth’s story all about what that future could look like. 

If you want to learn more, register now to join our next exclusive subscriber-only Roundtable discussion at 11.30ET today! Niall and our editorial director Allison Arieff will be talking about games without limits, the future of play, and much more.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Big Tech firms are going all-in on experimental clean energy projects
Due to the fact AI is so horribly polluting. But the projects range from ‘long shot’ to ‘magical thinking’. (WP $)
Making the grid smarter, rather than bigger, could help. (Semafor)
How virtual power plants are shaping tomorrow’s energy system. (MIT Technology Review)

2 Google is about to be hit with a ton of AI-related lawsuits
Its AI Overviews keep libeling people—and they’re lawyering up. (The Atlantic $)
Why Google’s AI Overviews gets things wrong. (MIT Technology Review)
Another AI-powered search engine, Perplexity, is running into the exact same issues. (Wired $)
Worst of all? There’s currently no way to fix the underlying problem. (MIT Technology Review)

3 Apple is exploring a deal with Meta
To integrate Meta’s generative AI models into Apple Intelligence. (Wall Street Journal $)
Apple is delaying launching AI features in Europe due to regulatory concerns. (Quartz)

4 NASA is indefinitely delaying the return of Starliner
In order to give it more time to review data. (Ars Technica)

5 Chinese tech companies are pushing their staff beyond breaking point
As growth slows and competition rises, work-life balance is going out the window. (FT $)

6 Used electric vehicles are now less expensive than gas cars in the US
It’s a worrying statistic that reflects the cratering demand for EVs. (Insider $)
The problem with plug-in hybrids? Their drivers. (MIT Technology Review)

7 Check out these photos of San Francisco’s AI scene
The city is currently buzzing with people hoping to make their fortune off the back of the boom. (WP $)

8 The next wave of weight loss drugs is coming
The hope is that they might be cheaper, and come with fewer side effects. (NBC)

9 Elon Musk is obsessed with getting us to have more babies
He’s funding

Read More

————

By: Charlotte Jee
Title: The Download: hyperrealistic deepfakes, and using math to shape wood
Sourced From: www.technologyreview.com/2024/06/24/1094179/the-download-hyperrealistic-deepfakes-math-shape-wood/
Published Date: Mon, 24 Jun 2024 12:10:00 +0000

Continue Reading

Tech

Is this the end of animal testing?

In a clean room in his lab, Sean Moore peers through a microscope at a bit of intestine, its dark squiggles and rounded structures standing out against a light gray background. This sample is not part of an actual intestine; rather, it’s human intestinal cells on a tiny plastic rectangle, one of 24 so-called “organs on chips” his lab bought three years ago.

Moore, a pediatric gastroenterologist at the University of Virginia School of Medicine, hopes the chips will offer answers to a particularly thorny research problem. He studies rotavirus, a common infection that causes severe diarrhea, vomiting, dehydration, and even death in young children. In the US and other rich nations, up to 98% of the children who are vaccinated against rotavirus develop lifelong immunity. But in low-income countries, only about a third of vaccinated children become immune. Moore wants to know why.

His lab uses mice for some protocols, but animal studies are notoriously bad at identifying human treatments. Around 95% of the drugs developed through animal research fail in people. Researchers have documented this translation gap since at least 1962. “All these pharmaceutical companies know the animal models stink,” says Don Ingber, founder of the Wyss Institute for Biologically Inspired Engineering at Harvard and a leading advocate for organs on chips. “The FDA knows they stink.”

But until recently there was no other option. Research questions like Moore’s can’t ethically or practically be addressed with a randomized, double-blinded study in humans. Now these organs on chips, also known as microphysiological systems, may offer a truly viable alternative. They look remarkably prosaic: flexible polymer rectangles about the size of a thumb drive. In reality they’re triumphs of bioengineering, intricate constructions furrowed with tiny channels that are lined with living human tissues. These tissues expand and contract with the flow of fluid and air, mimicking key organ functions like breathing, blood flow, and peristalsis, the muscular contractions of the digestive system.

More than 60 companies now produce organs on chips commercially, focusing on five major organs: liver, kidney, lung, intestines, and brain. They’re already being used to understand diseases, discover and test new drugs, and explore personalized approaches to treatment.

As they continue to be refined, they could solve one of the biggest problems in medicine today. “You need to do three things when you’re making a drug,” says Lorna Ewart, a pharmacologist and chief scientific officer of Emulate, a biotech company based in Boston. “You need to show it’s safe. You need to show it works. You need to be able to make it.”

All new compounds have to pass through a preclinical phase, where they’re tested for safety and effectiveness before moving to clinical trials in humans. Until recently, those tests had to run in at least two animal species—usually rats and dogs—before the drugs were tried on people.

But in December 2022, President Biden signed the FDA Modernization Act, which amended the original FDA Act of 1938. With a few small word changes, the act opened the door for non-animal-based testing in preclinical trials. Anything that makes it faster and easier for pharmaceutical companies to identify safe and effective drugs means better, potentially cheaper treatments for all of us.

Moore, for one, is banking on it, hoping the chips help him and his colleagues shed light on the rotavirus vaccine responses that confound them. “If you could figure out the answer,” he says, “you could save a lot of kids’ lives.”

While many teams have worked on organ chips over the last 30 years, the OG in the field is generally acknowledged to be Michael Shuler, a professor emeritus of chemical engineering at Cornell. In the 1980s, Shuler was a math and engineering guy who imagined an “animal on a chip,” a cell culture base seeded with a variety of human cells that could be used for testing drugs. He wanted to position a handful of different organ cells on the same chip, linked to one another, which could mimic the chemical communication between organs and the way drugs move through the body. “This was science fiction,” says Gordana Vunjak-Novakovic, a professor of biomedical engineering at Columbia University whose lab works with cardiac tissue on chips. “There was no body on a chip. There is still no body on a chip. God knows if there will ever be a body on a chip.”

Shuler had hoped to develop a computer model of a multi-organ system, but there were too many unknowns. The living cell culture system he dreamed up was his bid to fill in the blanks. For a while he played with the concept, but the materials simply weren’t good enough to build what he imagined.

“You can force mice to menstruate, but it’s not really menstruation. You need the human being.”

Linda Griffith, founding

Read More

————

By: Harriet Brown
Title: Is this the end of animal testing?
Sourced From: www.technologyreview.com/2024/06/21/1093419/animal-testing-organ-on-chip-research/
Published Date: Fri, 21 Jun 2024 09:00:00 +0000

Continue Reading

Trending