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This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

The lucky break behind the first CRISPR treatment

The world’s first commercial gene-editing treatment is set to start changing the lives of people with sickle-cell disease. It’s called Casgevy, and it was approved last month in the UK. US approval is pending this week.

The treatment, which will be sold in the US by Vertex Pharmaceuticals, employs CRISPR, which can be easily programmed by scientists to cut DNA at precise locations they choose.

But where do you aim CRISPR, and how did the researchers know what DNA to change? That’s the lesser-known story of the sickle-cell breakthrough, which doesn’t rely on fixing the genes responsible for the mutation that leaves patients’ hemoglobin molecules misshapen. Instead, it’s a kind of molecular bank shot—thankfully, one with a happy ending. Read the full story.

—Antonio Regalado

Read more about the sickle-cell breakthrough:

+ I received the new gene-editing drug for sickle cell disease. It changed my life. As a patient enrolled in a clinical trial for Vertex’s new exa-cel treatment, Jimi Olaghere was among the first to experience CRISPR’s transformative effects. Read the full story.

+ The first CRISPR cure might kick-start the next big patent battle. Vertex Pharmaceuticals plans to sell a gene-editing treatment for sickle-cell disease. A patent on CRISPR could stand in the way. Read the full story.

These robots know when to ask for help

The news: A new robot training model, dubbed “KnowNo,” aims to teach robots to ask for our help when orders are unclear. At the same time, it ensures they seek clarification only when necessary, minimizing needless back-and-forth. The result is a smart assistant that tries to make sure it understands what you want without bothering you too much.

Why it matters: While robots can be powerful in many specific scenarios, they are often bad at generalized tasks that require common sense. That’s something large language models could help to fix, because they have a lot of common-sense knowledge baked in. Read the full story.

—June Kim

Medical microrobots that travel inside the body are (still) on their way

The human body is a labyrinth of vessels and tubing, full of barriers that are difficult to break through. That poses a serious hurdle for doctors. Illness is often caused by problems that are hard to visualize and difficult to access. But imagine if we could deploy armies of tiny robots into the body to do the job for us. They could break up hard-to-reach clots, deliver drugs to even the most inaccessible tumors, and even help guide embryos toward implantation.

We’ve been hearing about the use of tiny robots in medicine for years, maybe even decades. And they’re still not here. But experts are adamant that medical microbots are finally coming, and that they could be a game changer for a number of serious diseases. Read the full story.

—Cassandra Willyard

This story is from The Checkup, our weekly biotech newsletter. Sign up to receive it in your inbox every Thursday.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Use of deepfake pornography apps is soaring  
Links to the disturbing AI ‘nudifying’ services are rife on X and Reddit. (Bloomberg $)
The viral AI avatar app Lensa undressed me—without my consent. (MIT Technology Review)

2 TikTok is embarking on an anti-hate speech campaign
Spurred by the criticism the platform received over Israel-Hamas videos (The Information $)
TikTok’s algorithm means everyone’s feed is siloed, though. (The Verge)
The conflict has forced Meta’s oversight board to investigate two posts. (Wired $)
Republicans are repeating bogus claims to try and get TikTok banned. (Motherboard)

3 A major Abu Dhabi-based AI company is cutting ties with China
G42 is ditching its Chinese hardware contracts in favor of US suppliers. (FT $)

4 We’re learning more about how vaping affects us
It’s better than smoking. But that doesn’t mean it’s good for you, either. (New Scientist $)
Social media is full of posts promoting vaping to young users. (The Guardian)

5 The US wants to build the next revolutionary particle collider
But it could take years to get the project off the ground. (NYT $)

6 The Milky Way is likely to devour the galaxies surrounding it
It’s looking like dark matter could have something to do with it. (Ars Technica)

7 Our microbiomes aren’t diverse enough
And our sedentary lifetimes and antibiotics are to blame. (Proto.Life)
We’re learning a lot more about the vaginal microbiome. (Scientific American $)
How gene-edited microbiomes could

Read More

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By: Rhiannon Williams
Title: The Download: inside the first CRISPR treatment, and smarter robots
Sourced From: www.technologyreview.com/2023/12/08/1084760/the-download-inside-the-first-crispr-treatment-and-smarter-robots/
Published Date: Fri, 08 Dec 2023 13:10:00 +0000

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Top 5 Bitcoin ATM Locations in Athens for Fast and Easy Crypto Access

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As a crypto analyst and frequent investor in the Greek digital currency market, I can confidently recommend Bcash for convenient and secure Bitcoin purchasing in Athens. With 10 strategically located crypto ATM hotspots spanning central Athens and the northern suburbs, Bcash enables instant access to leading cryptocurrencies like BTC, ETH, and USDT.

Experience the Leading Greek Crypto ATM Network at Bcash’s Hotspots

From first-hand experience, I’m impressed by Bcash’s easy user interface, excellent customer assistance, and fair prices. Their two-way ATM machines allow both buying with Euro cash and selling crypto for instant fiat payouts. I found the simple on-screen instructions enabled completing transactions in under 2 minutes!

Bcash’s Bitcoin ATM network stands out from competitors by aligning prices closely with real-time crypto market rates. Their typical 6-8% fees are much cheaper than traditional crypto brokers and exchanges in Greece. For investors seeking reliable local crypto access, Bcash has the solutions.

Central Athens Bcash Shops Offer Prime Buying and Selling

For maximum security while buying or selling Bitcoin, Bcash’s dedicated Athens shop locations are ideal. Their main office on Dimitrakopoulou Street in the city center contains a premier crypto ATM location open 6 days weekly. It’s close to public transit for easy access.

I also frequented Bcash’s Glyfada branch in the south shopping district. With spacious storefront access and long business hours, this hotspot proved one of my favorite crypto transaction destinations. The expert staff helped guide my buying process as a beginner too.

Glyfada Shopping District ATM Location

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The Glyfada store sits right on Gennimata Street, providing a safe and high-traffic venue for easily buying and selling leading cryptocurrencies. Open Monday through Saturday, this major Bcash outlet enjoys strong local area visibility for crypto investors.

Northern Suburbs ATM Hotspots

In Athens’ northern suburbs, I purchased Bitcoin multiple times at Bcash’s Nea Erythraia shop off Mikras Asias Street. Located just 20 minutes from the city center, it makes crypto conveniently accessible for residents across northeast Athens.

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Piraeus Port Shopping District ATM

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While recently docking overnight at the Piraeus cruise port as part of an Aegean island-hopping vacation, I encountered one of Bcash’s handy crypto ATMs just 5 minutes from the passenger terminals. Located right on Sachtouri Street inside the company’s Piraeus store, this machine proved hugely convenient for buying Bitcoin during my stay.

As one of Europe’s largest passenger ports, Piraeus receives over 4 million travelers every year who could benefit from easy access to crypto. Whether before boarding ferries to venture deeper into the Greek islands or arriving back onshore in Athens, the Bcash outlet enables obtaining coins to capture optimal valuations.

And for tourists exploring downtown Piraeus’ vast harborfront retail area, having a trusted Bitcoin ATM one block away gives peace of mind. Rather than relying solely on airport kiosks, cruise ship visitors can turn Euros into crypto almost anytime thanks to Bcash’s strategic positioning. As vacationing investors, that accessibility offers real advantages.

Bcash Brings Bitcoin to the Greek Islands

Rhodes Island BTM Location

Read More

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By: CryptoNinjas.net
Title: Top 5 Bitcoin ATM Locations in Athens for Fast and Easy Crypto Access
Sourced From: www.cryptoninjas.net/2024/03/03/top-5-bitcoin-atm-locations-in-athens-for-fast-and-easy-crypto-access/
Published Date: Sun, 03 Mar 2024 17:18:46 +0000

Did you miss our previous article…
https://mansbrand.com/the-citizen-scientists-chronicling-a-neglected-but-vital-mexican-river/

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The citizen scientists chronicling a neglected but vital Mexican river

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The city of Monterrey in northeastern Mexico is an industrial powerhouse that has rapidly devoured green space to make room for its 5.3 million people. The Sierra Madre Oriental mountain range around the city is still holding strong, though the hills are increasingly encroached on by the urban sprawl of skyscrapers, apartment buildings, industrial parks, and highways. The same can’t be said for the Río Santa Catarina, the river that has been the vital core of the city for hundreds of years.

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Lizbeth Ovalle, founder of Viaje al Microcosmos, gathers water from
the Río Santa CatarinaANDREA VILLARREAL
circle of approx 25 people seated on the rocky shore of a river
Participants in one of the Viaje al Microcosmos river walks sit to share their observations and reflect on their findings.
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Andrea Villarreal, a member of the citizen science group, shows a participant how to use the iNaturalist app, which can help identify plants and animals.

overgrowth in the area below an overpass
Viaje al Micrososmos
organized a walk along this stretch of the Río Santa Catarina in October 2023.LORENA RíOS

Today, the Río Santa Catarina looks more like a forest than a river. It is mostly a dry jumble of rocks whose water is diverted to supply the city’s growing needs. Much of the riverbed is obscured by vegetation that has grown wild since a hurricane in 2010 destroyed many structures along the river, including soccer fields, parking lots, and a mini-golf course. But despite what many city officials and residents make of it, this urban river is very much alive, and a group of young women wants to prove it.

The group, called Viaje al Microcosmos de Nuevo LeónJourney into the Microcosm of Nuevo León), is not made up of scientists but, rather, of concerned citizens. Through the use of art and citizen science, its members are documenting and sharing with others the river’s forgotten nature—its trees, bushes, birds, flowers, insects, and even microorganisms (from which the group takes its name).

IMG 8109 scaledRead More

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By: Lorena Ríos
Title: The citizen scientists chronicling a neglected but vital Mexican river
Sourced From: www.technologyreview.com/2024/02/28/1088234/monterrey-mexico-rio-santa-catarina-viaje-al-microcosmos/
Published Date: Wed, 28 Feb 2024 10:00:00 +0000

Did you miss our previous article…
https://mansbrand.com/what-luddites-can-teach-us-about-resisting-an-automated-future/

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What Luddites can teach us about resisting an automated future

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A story in comic format. In this first panel, two figures in silhouette look out at a modern city skyline.  The text reads,

A person's smiling headshot being uploaded.  The text reads,

The headshot from the previous panel with distroted features and a wavy new background. The text reads,

Two people look at the blank space where the framed picture of a flower has been stolen by a giant robot hand. The text reads,

Two panels. In the first, a scrabbly line resembling a signature. The text reads,

The text reads,

Text across the top continues, Read More

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By: Tom Humberstone
Title: What Luddites can teach us about resisting an automated future
Sourced From: www.technologyreview.com/2024/02/28/1088262/luddites-resisting-automated-future-technology/
Published Date: Wed, 28 Feb 2024 10:00:00 +0000

Did you miss our previous article…
https://mansbrand.com/the-worlds-most-famous-concert-pianos-got-a-major-tech-upgrade/

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