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This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

How inverse vaccines might tackle diseases like multiple sclerosis

On the whole, typical vaccines prime the immune system to respond. But scientists are also working on “inverse vaccines” that teach the immune system to stand down.

Last week Jeffrey Hubbell and his colleagues at the University of Chicago reported that an inverse vaccine they developed had successfully reversed a disease similar to multiple sclerosis in mice. Hubbell has tested this approach before, but only as a way of preventing the disease—not curing it.

These immune-dampening shots could lead to a whole host of therapies to treat autoimmune diseases. And in fact, Anokion, a company Hubbell cofounded, has already launched clinical trials to test whether this type of inverse vaccine might help people with multiple sclerosis and celiac disease. Read the full story.

—Cassandra Willyard

This story is from The Checkup, our weekly biotech and health newsletter. Sign up to receive it in your inbox every Thursday.

To learn more about vaccines, why not check out:

+ What to know about this autumn’s covid vaccines. New variants will pose a challenge, but early signs suggest the shots will still boost antibody responses. Read the full story.

+ Who benefits most from the new covid vaccines? Data show that older adults and people with underlying illnesses need the vaccine most. Read the full story.

+ What’s next for mRNA vaccines. mRNA vaccines helped us through the covid-19 pandemic—but they could also help defend against many other infectious diseases, offer universal protection against flu, and even treat cancer. Read the full story.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 The UK is revisiting Microsoft’s offer to acquire Activision
But it’s not a done deal yet. (WSJ $)
UK regulators have accepted Microsoft’s tweaks to the deal, in principle. (FT $)

2 The US has granted Ukraine a lot more military hardware
But long-range missiles, which Ukraine covets, won’t be included in the package. (ABC News)
The US equipment will plug the gap now Poland has ceased sending weapons. (Economist $)+ Decoy weapons are successfully fooling Russian troops. (FT $)
Inside the messy ethics of making war with machines. (MIT Technology Review)

3 The blockchain’s future looks surprisingly crypto-free
Startups have more modest goals now, ideally without legal complications. (Rest of World)+ Crypto parties are still raging if you know where to look, though. (Bloomberg $)

4 These law geeks are taking us inside Google’s antitrust trial
Google may have stopped the trial from being live streamed, but it can’t prevent members of the public from sitting in. (Wired $)

5 People are still queuing to buy the new iPhone
Lines of eager customers in China, the UK, Dubai and Australia suggest Apple’s appeal is as strong as ever. (Bloomberg $)

6 A man-made organism defies the rules of biology
In theory, using unnatural amino acids could make organisms less prone to viral infections. (Proto.Life)

7 Your intimate health information is just data to Big Tech
Data that can generally be sold onto willing advertisers. (The Atlantic $)
How your brain data could be used against you. (MIT Technology Review)

8 Gen Z isn’t immune to online scams
In fact, in many cases, they fall for them more than boomers. (Vox)

9 Absolutely nobody loves PowerPoint
Nonetheless, it persists. (FT $)
Next slide, please: A brief history of the corporate presentation. (MIT Technology Review)

10 Don’t throw out your used coffee grounds
They can become the foundation for all sorts of 3D-printing projects instead. (Ars Technica)
Watch this team of drones 3D-print a tower. (MIT Technology Review)

Quote of the day

“It feels bad, you feel hurt. Then you give yourself time to grieve, you find someone else and you get excited again.”

—Rowan Rosenthal, a former principal product designer for Grindr, likens the decision to leave the company because of its strict return-to-office mandate to the end of a relationship, they tell the Washington Post.

The big story

California’s coming offshore wind boom faces big engineering hurdles

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December 2022

Last December, dozens of companies fought for the right to lease the first commercial wind power sites off the coast of California in an auction

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By: Rhiannon Williams
Title: The Download: inverse vaccines, and Microsoft’s big deal
Sourced From: www.technologyreview.com/2023/09/22/1080043/the-download-inverse-vaccines-and-microsofts-big-deal/
Published Date: Fri, 22 Sep 2023 12:10:00 +0000

Did you miss our previous article…
https://mansbrand.com/bolstering-enterprise-llms-with-machine-learning-operations-foundations/

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The lucky break behind the first CRISPR treatment

dr. stuart orkin analyzing chromosomal spectra march 1985 crop jpg

The world’s first commercial gene-editing treatment is set to start changing the lives of people with sickle-cell disease. It’s called Casgevy, and it was approved last month in the UK. US approval is pending this week.

The treatment, which will be sold in the US by Vertex Pharmaceuticals, employs CRISPR, the Nobel-winning molecular scissors that have had journalists scrambling for metaphors: “Swiss Army knife,” “molecular scalpel,” or DNA copy-and-paste. Indeed, CRISPR is revolutionary because scientists can so easily program it to cut DNA at precise locations they choose.

But where do you aim CRISPR? That’s the lesser-known story of the sickle-cell breakthrough. The disease is caused by faulty hemoglobin, the molecule that carries oxygen in the blood. To cure it, though, Vertex and its partner company, CRISPR Therapeutics, aren’t fixing the genes responsible for the mutation that leaves those molecules misshapen. Instead, the new treatment involves a kind of molecular bank shot—an edit that turns on fetal hemoglobin, a second form of the molecule which we have in the womb but lose as adults.

You can think of how the edit works as a kind of double negative. It adds a misspelling to the turbo-booster of another gene, BCL11A, that is itself what inhibits the production of fetal hemoglobin in adult bodies. Without that booster, there’s less inhibition, and more fetal hemoglobin. Got it?

“When you inhibit the enhancer, you inhibit the inhibitor,” says Daniel Bauer, a professor at Boston Children’s Hospital and Harvard University, who helped work it out. “It is kind of complicated.”

The important thing is a happy ending—and this edit really works. Some patients say they lived in fear of dying, either from an acute attack of sickling (when their red blood cells start blocking vessels) or from slow, insidious organ damage. Now early volunteers say they’re grateful—and, after living with disease their whole lives, even a little shocked—to be cured.

Newborn theory

The idea that fetal hemoglobin can protect against the disease is an old one. Sickle-cell is most common in people with African ancestry. A doctor on Long Island, Janet Watson, had noticed in 1948 that newborns never showed its signs—the main one being misshapen, crescent-shaped red blood cells. That was pretty odd for an inborn condition.

“Sickle-cell disease should occur in infancy as often as later in life,” Watson wrote. But since it didn’t, Watson hypothesized that the fetal form of the molecule, active in the womb, was protecting babies for a few months after birth, until it was replaced by the adult version: “The theory that at once presents itself is that fetal hemoglobin is unable to produce sickling.”

She was right. But it took another six decades to learn how the switch-over worked—and how to flip it back. Many of those discoveries were made in the laboratory of Stuart Orkin, a Harvard researcher who published his first paper in 1967 and who’s lived through several eras of research on blood diseases, starting near the dawn of molecular biology.

“I am one of the last men standing,” Orkin told me with a grin when I met him for a corned-beef sandwich.

Dr. Stuart Orkin analyzing chromosomal spectra
Stuart Orkin analyzing DNA from individuals with blood disorders in his lab in 1985.BOSTON CHILDREN’S HOSPITAL

He’s a clever scientist who a long time ago decided to study how the blood system is regulated. Logistically, it was a great topic; blood cells are easy to get hold of and study.

“I like to solve a problem, and here is a problem that could be solved,” Orkin says. “How does the system work, and then can you do anything about it?”

Special sauce

Bill Lundberg, the former chief scientific officer of CRISPR Therapeutics, the biotech that first started developing the treatment eight years ago (Vertex later joined as a partner), says the company’s sickle-cell project directly made use of Orkin’s findings. “Stu’s role is really underappreciated,

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By: Antonio Regalado
Title: The lucky break behind the first CRISPR treatment
Sourced From: www.technologyreview.com/2023/12/07/1084629/lucky-break-crispr-vertex/
Published Date: Thu, 07 Dec 2023 14:00:09 +0000

Did you miss our previous article…
https://mansbrand.com/the-download-googles-gemini-is-here-and-sundar-pichai-talks-ai/

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The Download: Google’s Gemini is here, and Sundar Pichai talks AI

This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Google DeepMind’s new Gemini model looks amazing—but could signal peak AI hype

Hype about Gemini, Google DeepMind’s long-rumored response to OpenAI’s GPT-4, has been building for months. Now, the company has finally revealed what it has been working on in secret all this time. Was the hype justified? Yes—and no.

Gemini is Google’s biggest AI launch yet—its push to take on competitors OpenAI and Microsoft in the race for AI supremacy. There is no doubt that the model is pitched as best-in-class across a wide range of capabilities—an “everything machine.”

But while it’s a big step for Google, but not necessarily a giant leap for the field as a whole. Judging from its demos, it does many things very well—but few things that we haven’t seen before. Read the full story.

—Melissa Heikkiläa & Will Douglas Heaven

Google CEO Sundar Pichai on Gemini and the coming age of AI

This last year has largely been defined by the AI releases from one company: OpenAI. The rollout of DALL-E and GPT-3.5 last year, followed by GPT-4 this year, dominated the sector and kicked off an arms race between startups and tech giants alike

Now, with the release of Gemini, Google has thrown its hat into the ring. The new AI model reflects years of efforts from inside Google, overseen and driven by its CEO, Sundar Pichai.

Our editor-in-chief Mat Honan sat down with Pichai at Google’s offices in Mountain View, California, on the eve of Gemini’s launch to discuss what it will mean for the company, its products, AI, and society writ large. Read the full interview.

How carbon removal technology is like a time machine

By burning fossil fuels, we’ve released greenhouse gases by the gigaton. There’s a lot we can (and need to) do to slow and eventually stop these planet-warming emissions. But carbon removal technology has a different promise: turning the clock back.

Well, sort of. Carbon removal can’t literally take us back in time. But this time-machine analogy for thinking about carbon removal—specifically when it comes to the scale that will be needed to make a significant dent in our emissions—is a favorite of climate scientist David Ho.

Casey Crownhart, our climate reporter, has taken a look at what it might take for carbon removal to take us back far enough in time to reverse our mistakes—well, the emissions-related ones, anyway. Read the full story.

This story is from The Spark, our weekly climate and energy newsletter. Sign up to receive it in your inbox every Wednesday.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 The EU is racing to regulate AI 
Meanwhile, it seems like the US Congress is forging a very different regulatory path. (WP $)
EU lawmakers are believed to have made a provisional deal. (Reuters)
AI advances far more rapidly than policy. (NYT $)

2 Celebrities have been tricked into recording Russian propaganda
Trolls paid famous faces to record supportive clips for ‘Vladimir’ over the Cameo app. (WSJ $)
The clips rapidly spread across Russian networks and news organizations. (NYT $)

3 Startups are imploding all over the place
Once-promising multi-million dollar ventures are failing—and it’s only getting worse. (NYT $)

4 This man blew the whistle on Amazon’s abuse of teenager labor
But four years on, nothing has changed. (FT $)

5 A load of EVs are due to lose their tax credits
Cars with battery materials sourced from China will lose out on the $7,500 credit. (The Verge)
Ford doesn’t think its Mustang electric cars will qualify. (Reuters)+ EV tax credits could stall out on lack of US battery supply. (MIT Technology Review)

6 Building a gaming empire is seriously hard work
Just ask the TV streaming giants who are trying, and failing. (The Information $)

7 Forget microplastics—it’s time to worry about nanoplastics
Because they’re even smaller, they’re potentially even worse for our health. (Motherboard)
Microplastics are everywhere. What does that mean for our immune systems? (MIT Technology Review)

8 It’s time to revive the humble dry stone wall
Concrete isn’t great for the environment. Can stone walls take over? (The Atlantic $)
Inside a high-tech cement laboratory. (MIT Technology Review)

9 An AI drive-thru needed humans to handle 70% of its orders
It raises questions over how capable AI really is at these kinds of tasks. (Bloomberg $)
Even McDonald’s wants a slice of the generative AI pie. (The Verge)

10 Space telescopes are getting even bigger 
Move over JWST—the Extremely Large Telescope is here. (Economist $)

Quote of the day

“Even if Musk were

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————

By: Rhiannon Williams
Title: The Download: Google’s Gemini is here, and Sundar Pichai talks AI
Sourced From: www.technologyreview.com/2023/12/07/1084648/the-download-googles-gemini-is-here-and-sundar-pichai-talks-ai/
Published Date: Thu, 07 Dec 2023 13:10:00 +0000

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The Download: AI coding assistants, and China’s app disputes

This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Millions of coders are now using AI assistants. How will that change software?

Two weeks into the coding class he was teaching at Duke University in North Carolina this spring, Noah Gift told his students they’d no longer be working with Python, one of the most popular entry-level programming languages. Instead, they’d be using an AI tool called Copilot, a turbocharged autocomplete for computer code, to use Rust, a language that was newer, more powerful, and much harder to learn.

Gift isn’t alone. Ask a room of programmers if they use Copilot, and many now raise a hand. Like ChatGPT with education, Copilot is up-ending an entire profession by giving people new ways to perform old tasks.

With Microsoft and Google about to embed similar AI models into office software used by billions around the world, it’s worth asking exactly what these tools do for programmers. And just how big a difference will they make? Read the full story.

—Will Douglas Heaven

Chinese apps are letting public juries settle customer disputes

If you’ve ordered food through a delivery app lately, you’re probably familiar with the feeling of frustration when you have to wait too long for your order or, when you finally receive it, the food isn’t what you asked for. These feelings are then often exacerbated by the difficulty of trying to make things right via app.

Meituan, the most popular food delivery app in China, has proposed one solution: inviting ordinary users to serve on “juries” that weigh in on disputes between other customers and restaurants. It could be anything from missing rice to not-spicy-enough noodles to the food being completely cold.

And beyond helping resolve grievances for others, it turns out users are having quite a bit of fun being “cyber judges.” Read the full story.

—Zeyi Yang

This story is from China Report, our weekly newsletter giving you the inside track on all things tech in China. Sign up to receive it in your inbox every Tuesday.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Earth is lurching toward catastrophic climate tipping points
Once we breach them, experts warn it’ll unleash untold, irreversible damage. (The Guardian)
COP28 could be on the verge of promising to ban fossil fuels. (BBC)
The flawed logic of rushing out extreme climate interventions. (MIT Technology Review)

2 How to avoid a second OpenAI breakdown
A better board structure might be a good place to start. (Wired $)
Has it really only been a year since ChatGPT was released? (NYT $)
What’s next for OpenAI. (MIT Technology Review)

3 Alibaba’s new AI model is trained on TikTok dancers
It’s ripping off their work and creating a worse AI version. (404 Media)

4 Twitch is shutting down in South Korea
It’s one of the world’s largest esports markets, but running Twitch there is proving too expensive. (TechCrunch)

5 The carbon credit market is on the brink of booming
But a lack of guardrails mean many of its trades could end up being far from fair. (FT $)
The war in the Congo has kept the planet cooler. (The Atlantic $)
The growing signs of trouble for global carbon markets. (MIT Technology Review)

6 Minnesota mail workers aren’t allowed to blame Amazon for delays
They’ve been warned by postal management to keep schtum—or risk repercussions. (WP $)
Amazon workers are quitting in droves right now. (Insider $)
The company’s pilots are fed up too. (Wired $)

7 Meet the man who developed drugs to treat his children’s deadly disease
Now John Crowley has set his sights on making drug reviews faster and smoother. (WSJ $)
This family raised millions to get experimental gene therapy for their children. (MIT Technology Review)

8 What are we looking for in space?
When we say ‘life,’ we don’t really know what that looks like. (The Atlantic $)

9 You should beware crossing delivery drivers in Brazil
Or you might just find your home being bombarded by fireworks. (Rest of World)

10 Why it feels like your phone is bankrupting you
Phones used to be one-off purchases. Now, they demand more and more money from us. (NY Mag $)

Quote of the day

“It’s a heartwarming story of love, of loss, of hope and of joy. But most of all, it’s a wonderful sleep story.”

—The AI-generated voice of actor Jimmy Stewart recites a bedtime story for sleep and meditation app Calm, the New York Times reports.

The big story

This is how AI bias really happens—and why it’s so hard to fix

Read More

————

By: Rhiannon Williams
Title: The Download: AI coding assistants, and China’s app disputes
Sourced From: www.technologyreview.com/2023/12/06/1084461/the-download-ai-coding-assistants-and-chinas-app-disputes/
Published Date: Wed, 06 Dec 2023 13:10:00 +0000

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