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The pig heart transplanted into an American patient earlier this year in a landmark operation carried a porcine virus that may have derailed the experiment and contributed to his death two months later, say transplant specialists.

David Bennett Sr. was near death in January when he received a genetically edited pig heart in a pioneering between-species transplant that has been hailed as a success—and was, at first.

A few days after his heart was replaced with one from a pig, Bennett was sitting up in bed. His new heart was pumping fantastically and performing like a “rock star,” according to his transplant surgeon, Bartley Griffith of the University of Maryland School of Medicine.

But about 40 days later Bennett, who was 57, took a turn for the worse. After two months he was dead. In a statement released by the university in March, a spokesperson said there was “no obvious cause identified at the time of his death” and that a full report was pending.

Now MIT Technology Review has learned that Bennett’s heart was affected by porcine cytomegalovirus, a preventable infection that is linked to devastating effects on transplants.  

The presence of the pig virus and the desperate efforts to defeat it were described by Griffith during a webinar streamed online by the American Society of Transplantation on April 20. The issue is now a subject of wide discussion among specialists, who think the infection was a potential contributor to Bennett’s death and a possible reason why the heart did not last longer.

“We are beginning to learn why he passed on,” said Griffith, who believes that the virus “maybe was the actor, or could be the actor, that set this whole thing off.”

The heart swap in Maryland was a major test of xenotransplantation, the process of moving tissues between species. But because the special pigs raised to provide organs are supposed to be virus-free, it now appears that the experiment was compromised by an unforced error. The biotechnology company that raised and engineered the pigs, Revivicor, declined to comment and has made no public statement about the virus.

“It was surprising. That pig is supposed to be clean of all pig pathogens, and this is a significant one,” says Mike Curtis, CEO of eGenesis, a competing company that is also breeding pigs for transplant organs. “Without the virus, would Mr. Bennett have lived? We don’t know, but the infection didn’t help. It likely contributed to the failure.”

10-gene pig  

The detection of the pig virus in Bennett’s heart is not necessarily all bad news for xenotransplantation. If a pig virus played a role, it could mean a virus-free heart xenotransplant could last much longer. Some surgeons think the latest gene-modified organs could in theory keep beating for years—and more rigorous procedures should be able to screen out the virus.

“If this was an infection, we can likely prevent it in the future,” Griffith said during his presentation

The biggest obstacle to animal-organ transplants is the human immune system, which ferociously attacks foreign cells in a process called rejection. To avoid rejection, companies have been engineering pigs—removing some genes and adding others—to give their tissue a stealth profile that hides from immune attack.

The version used in Maryland came from a pig with 10 gene modifications developed by Revivicor, a subsidiary of United Therapeutics.

Following promising tests of such pig organs in baboons, three US transplant teams launched the first human studies starting in late 2021. Surgeons at New York University and the University of Alabama each attached pig kidneys to brain-dead people, but the University of Maryland went a step further when Griffith stitched a pig heart into Bennett’s chest in early January.

Transferring pig viruses to humans has been a worry—some fear xenotransplantation could set off a pandemic if a virus were to adapt inside a patient’s body and then spread to doctors and nurses. The concern could be serious enough to require lifelong monitoring for patients.

However, the specific type of virus found in Bennett’s donor heart is not believed capable of infecting human cells, says Jay Fishman, a specialist in transplant infections at Massachusetts General Hospital. Fishman thinks there is “no real risk to humans” of its spreading further.

Instead, the problem is that pig cytomegalovirus is linked to reactions that can damage the organ and the patient—with catastrophic results. Two years ago, for instance, German researchers reported that pig hearts transplanted into baboons lasted only a couple of weeks if the virus was present, while organs free from the infection could survive more than half a year.

Those researchers said they found “astonishingly high” virus levels in pig hearts removed from baboons. They

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By: Antonio Regalado
Title: The gene-edited pig heart given to a dying patient was infected with a pig virus
Sourced From: www.technologyreview.com/2022/05/04/1051725/xenotransplant-patient-died-received-heart-infected-with-pig-virus/
Published Date: Wed, 04 May 2022 19:00:00 +0000

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The Download: the year’s most-read climate stories, and Amazon’s chatbot

This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

A look back at the year’s most-read climate stories

2023 has been a big year for climate news. Wildfires, floods and heatwaves displaced and killed thousands of people across the world as extreme weather events worsened, and scientists have concluded the past 12 months were the hottest since records began.

But it’s not exclusively bad news. Our climate experts James Temple and Casey Crownhart have been covering the most promising technologies that could make a difference. Take a look back over some of MIT Technology Review’s most-read climate stories of the year—and make sure you keep up-to-date with all the latest news by subscribing to The Spark, our weekly climate and energy tech newsletter.

+ This geothermal startup showed its wells can be used like a giant underground battery. If Fervo Energy’s field results work at commercial scale, it could become cheaper and easier to green the grid. Read the full story.

+ Helion Energy, a startup backed by Sam Altman, says its first fusion plant is five years away. Experts aren’t so sure.

+ Check out our handy explainer of how heat pumps work—and how they could save you money in the process.

+ Spraying iron particles above the ocean could help to fight climate change. But scientists say far more research still needs to be done. Read the full story.

+ Yes, we have enough materials to power the world with renewable energy. We won’t run out of key ingredients for climate action, but mining comes with social and environmental ramifications. Read the full story.

+ Nonprofits and academic groups are working to help climate-vulnerable regions take part in the high-stakes global debate over solar geoengineering.

+ We were promised smaller nuclear reactors. Where are they? Small modular reactors could be quicker and cheaper to build. Now, they’ve reached a major milestone. Read the full story.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Amazon has launched a new AI chatbot called Q
Not to be confused with OpenAI’s rumored Q* AI model. (NYT $)
It’s designed to help code and manage cloud software for businesses. (Wired $)

2 Elon Musk boosted the dangerous pizzagate conspiracy theory
It’s the latest in a string of long-debunked theories he’s given oxygen to on X. (WP $)
It’s no wonder the platform can’t keep its advertisers. (Motherboard)

3 Apple is winding down its Goldman Sachs credit card partnership
But it’s unclear whether this spells the end of Apple’s foray into finance or not. (WSJ $)

4 There’s no evidence the internet is harming your mental health
Contrary to popular opinion. (FT $)
Your kid’s phone probably isn’t causing depression. (MIT Technology Review)

5 Amazon is disrupting rural mail services across America
Postal workers have been instructed to prioritize the retail giant’s package deliveries, and customers aren’t happy about it. (WP $)

6 High-profile women in AI don’t want to join OpenAI’s all-male board
The board reflects the wider problems within the AI industry. (Wired $)
A prominent female tech influencer’s accounts are run by a man. (404 Media)
Why can’t tech fix its gender problem? (MIT Technology Review)

7 America loves hydrogen 
It’s an attractive green energy—but only if it can be made efficiently. (The Atlantic $)
When hydrogen will help climate change—and when it won’t. (MIT Technology Review)

8 US soldiers are sharing their horrific barracks on a new app  
Hots&Cots is full of images of dirty lodgings and substandard living conditions. (Motherboard)
The future of military tech is heavily AI-based. (Vox)

9 The world’s first AI singer is no Taylor Swift
Her first release is deeply basic, to put it kindly. (Insider $)

10 Those Instagrammable offices aren’t fooling anyone
Workers don’t want to go back, and photogenic spaces won’t change that. (NYT $)

Quote of the day

“The list of abuses is endless…[X] has become a vast global sewer.”

—Anne Hidalgo, the mayor of Paris, explains why she’s leaving X after 14 years on the platform, Insider reports.

The big story

How robotic honeybees and hives could help the species fight back

XnY9S

October 2022

Something was wrong, but Thomas Schmickl couldn’t put his finger on it. It was 2007, and the Austrian biologist was spending part of the year at East Tennessee State

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By: Rhiannon Williams
Title: The Download: the year’s most-read climate stories, and Amazon’s chatbot
Sourced From: www.technologyreview.com/2023/11/29/1084048/the-download-the-years-most-read-climate-stories-and-amazons-chatbot/
Published Date: Wed, 29 Nov 2023 13:10:00 +0000

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Procurement in the age of AI

amazon business cart

Procurement professionals face challenges more daunting than ever. Recent years’ supply chain disruptions and rising costs, deeply familiar to consumers, have had an outsize impact on business buying. At the same time, procurement teams are under increasing pressure to supply their businesses while also contributing to business growth and profitability.

amazon business cart 1

Deloitte’s 2023 Global Chief Procurement Officer Survey reveals that procurement teams are now being called upon to address a broader range of enterprise priorities. These range from driving operational efficiency (74% of respondents) and enhancing corporate social responsibility (72%) to improving margins via cost reduction (71%).

To meet these rising expectations, many procurement teams are turning to advanced analytics, AI, and machine learning (ML) to transform the way they make smart business buying decisions and create value for the organization.

New procurement capabilities unlocked by AI

AI and ML tools have long helped procurement teams automate mundane and manual procurement processes, allowing them to focus on more strategic initiatives. But recent advances in natural language processing (NLP), pattern recognition, cognitive analytics, and large language models (LLMs) are “opening up opportunities to make procurement more efficient and effective,” says Julie Scully, director of software development at Amazon Business.

The good news is procurement teams are already well-positioned to capitalize on these technological advances. Their access to rich data sources, ranging from contracts to invoices, enables AI/ML solutions that can illuminate the insights contained within this data. Acting on these insights unlocks new capabilities that can enhance decision-making and improve spending patterns across the organization.

Predicting supply chain disruptions. In an era of constant supply chain disruptions, procurement teams are often faced with inconsistent item availability, which can negatively impact employee and customer experience. Indeed, the Deloitte 2023 Global Chief Procurement Officer survey finds that only 25% of firms are able to identify supply disruptions promptly “to a large extent.”

AI tools can help address this issue by recognizing patterns that indicate an emerging supply shortage and automatically recommending two or three product alternatives to business buyers, thereby preventing supply disruptions. These predictive capabilities also empower procurement teams to establish buying policies that proactively account for items that are more likely to go out of stock.

Answering pressing questions quickly. Sifting through data to understand the cause of a supply chain disruption, product defect, or other risk is time-consuming for a procurement professional. LLM-powered chatbots can streamline these processes by understanding complex queries about orders and “putting together a nuanced answer,” says Scully. “AI can query a wide variety of sources to fully answer a question quickly and in a way that feels natural and understandable.” In addition to providing fast and accurate answers to pressing questions, AI promises to reduce the need to explain procurement issues eventually. Instead, it will proactively analyze orders, buying patterns, and the current situation to provide instant support.

Offering customized recommendations. As business buyers increasingly demand personalized experiences, procurement officers seek ways to customize their interactions with business procurement systems. Scully provides the example of an employee tasked with hosting a holiday party for 150 employees who needs help deciding what to order. An AI-based procurement tool posed that scenario, she says, could generate a proposed shopping cart, sifting through “millions and billions of data points to recommend and suggest items that the employee may not have even thought of.”

Better yet, she adds, “as we get into really large language models, AI/ML can help answer questions or help buy items you didn’t even know you needed by understanding your particular situation in a much more detailed way.”

Influencing compliance spend. Procurement professionals aim to balance employees’ freedom to purchase the items they need with minimal intervention. However, self-sufficiency should not come at the cost of proper spend

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By: MIT Technology Review Insights
Title: Procurement in the age of AI
Sourced From: www.technologyreview.com/2023/11/28/1083628/procurement-in-the-age-of-ai/
Published Date: Tue, 28 Nov 2023 16:00:00 +0000

Did you miss our previous article…
https://mansbrand.com/the-download-cop28-controversy-and-the-future-of-families/

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The Download: COP28 controversy and the future of families

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This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Why the UN climate talks are a moment of reckoning for oil and gas companies

The United Arab Emirates is one of the world’s largest oil producers. It’s also the site of this year’s UN COP28 climate summit, which kicks off later this week in Dubai.

It’s a controversial host, but the truth is that there’s massive potential for oil and gas companies to help address climate change, both by cleaning up their operations and by investing their considerable wealth and expertise into new technologies.

The problem is that these companies also have a vested interest in preserving the status quo. If they want to be part of a net-zero future, something will need to change—and soon. Read the full story.

—Casey Crownhart

How reproductive technology can reverse population decline

Birth rates have been plummeting in wealthy countries, well below the “replacement” rate. Even in China, a dramatic downturn in the number of babies has officials scrambling, as its population growth turns negative.

So, what’s behind the baby bust and can new reproductive technology reverse the trend? MIT Technology Review is hosting a subscriber-only Roundtables discussion on how innovations from the lab could affect the future of families at 11am ET this morning, featuring Antonio Regalado, our biotechnology editor, and entrepreneur Martín Varsavsky, founder of fertility clinic Prelude Fertility. Don’t miss out—make sure you register now.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Instagram recommends sexual content to adults that follow kids

Test accounts were served risqué posts and disturbing videos. (WSJ $)
Meta was aware it had millions of underage users, a complaint alleges. (NYT $)

2  The first transatlantic flight powered by alternative fuels has taken off
Waste fats and corn leftovers are fueling the flight between London and New York. (BBC)
Here are the key phrases you need to know to understand climate change. (Vox)
Everything you need to know about the wild world of alternative jet fuels. (MIT Technology Review)

3 The United Arab Emirates planned to strike oil deals during COP28 
Which doesn’t seem terribly climate-friendly. (BBC)
AUAE AI firm is believed to have covertly worked with Chinese companies. (NYT $)
China’s own carbon emissions are on course to peak soon. (Economist $)

4 Starlink can only operate in Gaza with Israel’s approval
That’s according to Elon Musk, who is visiting Israel currently. (FT $) 

5 Foxconn is struggling to build iPhones in India
So the manufacturer started shipping over skilled workers from China. (Rest of World)

6 The world’s banana supply is in serious trouble
🍌
A deadly fungus is sweeping through crops—and there’s no known cure. (Bloomberg $)

7 Digital car keys don’t always work the way they’re supposed to
Which is a major problem if you can’t guarantee your vehicle is secure. (The Verge)

8 It’s not just you—dating is tough
But these tips can help to make it a less harrowing experience. (WP $)
Here’s how the net’s newest matchmakers help you find love. (MIT Technology Review)

9 Big dogs don’t live that long
🐶
But biotech company Loyal is hoping to change that with an experimental drug. (Wired $)
These scientists are working to extend the life span of pet dogs—and their owners. (MIT Technology Review)

10 The quiet bliss of living in an internet-free home
And how you can achieve it, too. (The Atlantic $)
How to log off. (MIT Technology Review)

Quote of the day

“He ignored me royally, which is his privilege. And he lost almost all the money that he had invested.”

—Christine Lagarde, president of the European Central Bank, explains to students in Frankfurt how one of her sons lost his money on crypto, despite her repeated warnings, Reuters reports.

The big story

Are you ready to be a techno-optimist again?

February 2021

Back in 2001, MIT Technology Review picked 10 emerging areas of innovation that we promised would “change the world.” It was a time of peak techno-optimism.

We eschewed

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By: Rhiannon Williams
Title: The Download: COP28 controversy and the future of families
Sourced From: www.technologyreview.com/2023/11/28/1083923/the-download-cop28-controversy-and-the-future-of-families/
Published Date: Tue, 28 Nov 2023 13:10:00 +0000

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