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In January 2023, Tara Sweeney’s plane landed on Thwaites Glacier, a 74,000-square-mile mass of frozen water in West Antarctica. She arrived with an international research team to study the glacier’s geology and ice fabric, and how its ice melt might contribute to sea level rise. But while near Earth’s southernmost point, Sweeney kept thinking about the moon.

“It felt every bit of what I think it will feel like being a space explorer,” said Sweeney, a former Air Force officer who’s now working on a doctorate in lunar geology at the University of Texas at El Paso. “You have all of these resources, and you get to be the one to go out and do the exploring and do the science. And that was really spectacular.”

That similarity is why space scientists study the physiology and psychology of people living in Antarctic and other remote outposts: For around 25 years, people have played out what existence might be like on, or en route to, another world. Polar explorers are, in a way, analogous to astronauts who land on alien planets. And while Sweeney wasn’t technically on an “analog astronaut” mission — her primary objective being the geological exploration of Earth — her days played out much the same as a space explorer’s might.

For 16 days, Sweeney and her colleagues lived in tents on the ice, spending half their time trapped inside as storms blew snow against their tents. When the weather permitted, Sweeney snowmobiled to and from seismometer sites, once getting caught in a whiteout that, she said, felt like zooming inside a ping-pong ball.

On the glacier, Sweeney was always cold, sometimes bored, often frustrated. But she was also alive, elated. And she felt a form of focus that eluded her on her home continent. “I had three objectives: to be a good crewmate, to do good science, and to stay alive,” she said. “That’s all I had to do.”

None of that was easy, of course. But it may have been easier than landing back on the earth of El Paso. “My mission ended, and it’s over,” she said. “And how do I process through all these things that I’m feeling?”

Then, in May, she attended the 2023 Analog Astronaut Conference, a gathering of people who simulate long-term space travel from the relative safety and comfort of Earth. Sweeney had learned about the event when she visited an analog facility in the country of Jordan. There, she’d met one of the conference’s founders, Jas Purewal, who invited her to the gathering.

The meeting was held, appropriately, at Biosphere 2, a glass-paneled, self-contained habitat in the Arizona desert that resembles a 1980s sci-fi vision of a space settlement — one of the first facilities built, in part, to understand whether humans could create a habitable environment on a hostile planet.

wide view of the Biosphere 2 facilities
The 40-acre Biosphere 2 campus in Oracle, Arizona. It was one of the first facilities built for analog astronaut missions. UNIVERSITY OF ARIZONA

A speaker at the conference had spent eight months locked inside a simulated space habitat in Moscow, Russia, and she talked about how the post-mission period had been hard for her. The psychological toll of reintegration became a chattering theme throughout the whole meeting. Sweeney, it turned out, wasn’t alone.

Across the world, around 20 analog space facilities host people who volunteer to be study subjects, isolating themselves for weeks or months in polar stations, desert outposts, or even sealed habitats inside NASA centers. These places are intended to mimic how people might fare on Mars or the moon, or on long-term orbital stations. Such research, scientists say, can help test out medical and software tools, enhance indoor agriculture, and address the difficulties analog astronauts face, including, like Sweeney’s, those that come when their “missions” are over.

Lately, a community of researchers has started to make the field more formalized: laying out standards so that results are comparable; gathering research papers into a single database so investigators can

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By: Sarah Scoles
Title: These scientists live like astronauts without leaving Earth
Sourced From: www.technologyreview.com/2023/09/22/1080035/scientists-live-like-astronauts-without-leaving-earth/
Published Date: Fri, 22 Sep 2023 15:38:48 +0000

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The lucky break behind the first CRISPR treatment

dr. stuart orkin analyzing chromosomal spectra march 1985 crop jpg

The world’s first commercial gene-editing treatment is set to start changing the lives of people with sickle-cell disease. It’s called Casgevy, and it was approved last month in the UK. US approval is pending this week.

The treatment, which will be sold in the US by Vertex Pharmaceuticals, employs CRISPR, the Nobel-winning molecular scissors that have had journalists scrambling for metaphors: “Swiss Army knife,” “molecular scalpel,” or DNA copy-and-paste. Indeed, CRISPR is revolutionary because scientists can so easily program it to cut DNA at precise locations they choose.

But where do you aim CRISPR? That’s the lesser-known story of the sickle-cell breakthrough. The disease is caused by faulty hemoglobin, the molecule that carries oxygen in the blood. To cure it, though, Vertex and its partner company, CRISPR Therapeutics, aren’t fixing the genes responsible for the mutation that leaves those molecules misshapen. Instead, the new treatment involves a kind of molecular bank shot—an edit that turns on fetal hemoglobin, a second form of the molecule which we have in the womb but lose as adults.

You can think of how the edit works as a kind of double negative. It adds a misspelling to the turbo-booster of another gene, BCL11A, that is itself what inhibits the production of fetal hemoglobin in adult bodies. Without that booster, there’s less inhibition, and more fetal hemoglobin. Got it?

“When you inhibit the enhancer, you inhibit the inhibitor,” says Daniel Bauer, a professor at Boston Children’s Hospital and Harvard University, who helped work it out. “It is kind of complicated.”

The important thing is a happy ending—and this edit really works. Some patients say they lived in fear of dying, either from an acute attack of sickling (when their red blood cells start blocking vessels) or from slow, insidious organ damage. Now early volunteers say they’re grateful—and, after living with disease their whole lives, even a little shocked—to be cured.

Newborn theory

The idea that fetal hemoglobin can protect against the disease is an old one. Sickle-cell is most common in people with African ancestry. A doctor on Long Island, Janet Watson, had noticed in 1948 that newborns never showed its signs—the main one being misshapen, crescent-shaped red blood cells. That was pretty odd for an inborn condition.

“Sickle-cell disease should occur in infancy as often as later in life,” Watson wrote. But since it didn’t, Watson hypothesized that the fetal form of the molecule, active in the womb, was protecting babies for a few months after birth, until it was replaced by the adult version: “The theory that at once presents itself is that fetal hemoglobin is unable to produce sickling.”

She was right. But it took another six decades to learn how the switch-over worked—and how to flip it back. Many of those discoveries were made in the laboratory of Stuart Orkin, a Harvard researcher who published his first paper in 1967 and who’s lived through several eras of research on blood diseases, starting near the dawn of molecular biology.

“I am one of the last men standing,” Orkin told me with a grin when I met him for a corned-beef sandwich.

Dr. Stuart Orkin analyzing chromosomal spectra
Stuart Orkin analyzing DNA from individuals with blood disorders in his lab in 1985.BOSTON CHILDREN’S HOSPITAL

He’s a clever scientist who a long time ago decided to study how the blood system is regulated. Logistically, it was a great topic; blood cells are easy to get hold of and study.

“I like to solve a problem, and here is a problem that could be solved,” Orkin says. “How does the system work, and then can you do anything about it?”

Special sauce

Bill Lundberg, the former chief scientific officer of CRISPR Therapeutics, the biotech that first started developing the treatment eight years ago (Vertex later joined as a partner), says the company’s sickle-cell project directly made use of Orkin’s findings. “Stu’s role is really underappreciated,

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By: Antonio Regalado
Title: The lucky break behind the first CRISPR treatment
Sourced From: www.technologyreview.com/2023/12/07/1084629/lucky-break-crispr-vertex/
Published Date: Thu, 07 Dec 2023 14:00:09 +0000

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https://mansbrand.com/the-download-googles-gemini-is-here-and-sundar-pichai-talks-ai/

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The Download: Google’s Gemini is here, and Sundar Pichai talks AI

This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Google DeepMind’s new Gemini model looks amazing—but could signal peak AI hype

Hype about Gemini, Google DeepMind’s long-rumored response to OpenAI’s GPT-4, has been building for months. Now, the company has finally revealed what it has been working on in secret all this time. Was the hype justified? Yes—and no.

Gemini is Google’s biggest AI launch yet—its push to take on competitors OpenAI and Microsoft in the race for AI supremacy. There is no doubt that the model is pitched as best-in-class across a wide range of capabilities—an “everything machine.”

But while it’s a big step for Google, but not necessarily a giant leap for the field as a whole. Judging from its demos, it does many things very well—but few things that we haven’t seen before. Read the full story.

—Melissa Heikkiläa & Will Douglas Heaven

Google CEO Sundar Pichai on Gemini and the coming age of AI

This last year has largely been defined by the AI releases from one company: OpenAI. The rollout of DALL-E and GPT-3.5 last year, followed by GPT-4 this year, dominated the sector and kicked off an arms race between startups and tech giants alike

Now, with the release of Gemini, Google has thrown its hat into the ring. The new AI model reflects years of efforts from inside Google, overseen and driven by its CEO, Sundar Pichai.

Our editor-in-chief Mat Honan sat down with Pichai at Google’s offices in Mountain View, California, on the eve of Gemini’s launch to discuss what it will mean for the company, its products, AI, and society writ large. Read the full interview.

How carbon removal technology is like a time machine

By burning fossil fuels, we’ve released greenhouse gases by the gigaton. There’s a lot we can (and need to) do to slow and eventually stop these planet-warming emissions. But carbon removal technology has a different promise: turning the clock back.

Well, sort of. Carbon removal can’t literally take us back in time. But this time-machine analogy for thinking about carbon removal—specifically when it comes to the scale that will be needed to make a significant dent in our emissions—is a favorite of climate scientist David Ho.

Casey Crownhart, our climate reporter, has taken a look at what it might take for carbon removal to take us back far enough in time to reverse our mistakes—well, the emissions-related ones, anyway. Read the full story.

This story is from The Spark, our weekly climate and energy newsletter. Sign up to receive it in your inbox every Wednesday.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 The EU is racing to regulate AI 
Meanwhile, it seems like the US Congress is forging a very different regulatory path. (WP $)
EU lawmakers are believed to have made a provisional deal. (Reuters)
AI advances far more rapidly than policy. (NYT $)

2 Celebrities have been tricked into recording Russian propaganda
Trolls paid famous faces to record supportive clips for ‘Vladimir’ over the Cameo app. (WSJ $)
The clips rapidly spread across Russian networks and news organizations. (NYT $)

3 Startups are imploding all over the place
Once-promising multi-million dollar ventures are failing—and it’s only getting worse. (NYT $)

4 This man blew the whistle on Amazon’s abuse of teenager labor
But four years on, nothing has changed. (FT $)

5 A load of EVs are due to lose their tax credits
Cars with battery materials sourced from China will lose out on the $7,500 credit. (The Verge)
Ford doesn’t think its Mustang electric cars will qualify. (Reuters)+ EV tax credits could stall out on lack of US battery supply. (MIT Technology Review)

6 Building a gaming empire is seriously hard work
Just ask the TV streaming giants who are trying, and failing. (The Information $)

7 Forget microplastics—it’s time to worry about nanoplastics
Because they’re even smaller, they’re potentially even worse for our health. (Motherboard)
Microplastics are everywhere. What does that mean for our immune systems? (MIT Technology Review)

8 It’s time to revive the humble dry stone wall
Concrete isn’t great for the environment. Can stone walls take over? (The Atlantic $)
Inside a high-tech cement laboratory. (MIT Technology Review)

9 An AI drive-thru needed humans to handle 70% of its orders
It raises questions over how capable AI really is at these kinds of tasks. (Bloomberg $)
Even McDonald’s wants a slice of the generative AI pie. (The Verge)

10 Space telescopes are getting even bigger 
Move over JWST—the Extremely Large Telescope is here. (Economist $)

Quote of the day

“Even if Musk were

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By: Rhiannon Williams
Title: The Download: Google’s Gemini is here, and Sundar Pichai talks AI
Sourced From: www.technologyreview.com/2023/12/07/1084648/the-download-googles-gemini-is-here-and-sundar-pichai-talks-ai/
Published Date: Thu, 07 Dec 2023 13:10:00 +0000

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The Download: AI coding assistants, and China’s app disputes

This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Millions of coders are now using AI assistants. How will that change software?

Two weeks into the coding class he was teaching at Duke University in North Carolina this spring, Noah Gift told his students they’d no longer be working with Python, one of the most popular entry-level programming languages. Instead, they’d be using an AI tool called Copilot, a turbocharged autocomplete for computer code, to use Rust, a language that was newer, more powerful, and much harder to learn.

Gift isn’t alone. Ask a room of programmers if they use Copilot, and many now raise a hand. Like ChatGPT with education, Copilot is up-ending an entire profession by giving people new ways to perform old tasks.

With Microsoft and Google about to embed similar AI models into office software used by billions around the world, it’s worth asking exactly what these tools do for programmers. And just how big a difference will they make? Read the full story.

—Will Douglas Heaven

Chinese apps are letting public juries settle customer disputes

If you’ve ordered food through a delivery app lately, you’re probably familiar with the feeling of frustration when you have to wait too long for your order or, when you finally receive it, the food isn’t what you asked for. These feelings are then often exacerbated by the difficulty of trying to make things right via app.

Meituan, the most popular food delivery app in China, has proposed one solution: inviting ordinary users to serve on “juries” that weigh in on disputes between other customers and restaurants. It could be anything from missing rice to not-spicy-enough noodles to the food being completely cold.

And beyond helping resolve grievances for others, it turns out users are having quite a bit of fun being “cyber judges.” Read the full story.

—Zeyi Yang

This story is from China Report, our weekly newsletter giving you the inside track on all things tech in China. Sign up to receive it in your inbox every Tuesday.

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Earth is lurching toward catastrophic climate tipping points
Once we breach them, experts warn it’ll unleash untold, irreversible damage. (The Guardian)
COP28 could be on the verge of promising to ban fossil fuels. (BBC)
The flawed logic of rushing out extreme climate interventions. (MIT Technology Review)

2 How to avoid a second OpenAI breakdown
A better board structure might be a good place to start. (Wired $)
Has it really only been a year since ChatGPT was released? (NYT $)
What’s next for OpenAI. (MIT Technology Review)

3 Alibaba’s new AI model is trained on TikTok dancers
It’s ripping off their work and creating a worse AI version. (404 Media)

4 Twitch is shutting down in South Korea
It’s one of the world’s largest esports markets, but running Twitch there is proving too expensive. (TechCrunch)

5 The carbon credit market is on the brink of booming
But a lack of guardrails mean many of its trades could end up being far from fair. (FT $)
The war in the Congo has kept the planet cooler. (The Atlantic $)
The growing signs of trouble for global carbon markets. (MIT Technology Review)

6 Minnesota mail workers aren’t allowed to blame Amazon for delays
They’ve been warned by postal management to keep schtum—or risk repercussions. (WP $)
Amazon workers are quitting in droves right now. (Insider $)
The company’s pilots are fed up too. (Wired $)

7 Meet the man who developed drugs to treat his children’s deadly disease
Now John Crowley has set his sights on making drug reviews faster and smoother. (WSJ $)
This family raised millions to get experimental gene therapy for their children. (MIT Technology Review)

8 What are we looking for in space?
When we say ‘life,’ we don’t really know what that looks like. (The Atlantic $)

9 You should beware crossing delivery drivers in Brazil
Or you might just find your home being bombarded by fireworks. (Rest of World)

10 Why it feels like your phone is bankrupting you
Phones used to be one-off purchases. Now, they demand more and more money from us. (NY Mag $)

Quote of the day

“It’s a heartwarming story of love, of loss, of hope and of joy. But most of all, it’s a wonderful sleep story.”

—The AI-generated voice of actor Jimmy Stewart recites a bedtime story for sleep and meditation app Calm, the New York Times reports.

The big story

This is how AI bias really happens—and why it’s so hard to fix

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————

By: Rhiannon Williams
Title: The Download: AI coding assistants, and China’s app disputes
Sourced From: www.technologyreview.com/2023/12/06/1084461/the-download-ai-coding-assistants-and-chinas-app-disputes/
Published Date: Wed, 06 Dec 2023 13:10:00 +0000

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