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To be a great company founder, they say you should use your own product. Eat your own dog food. But what if you are running a biotech company developing an experimental fertility treatment? You might be excused.

Not Dina Radenkovic, CEO of Gameto, a New York startup engineering stem cells to craft a lightweight version of IVF, one it thinks could appeal to professional women without time to spare. Last December, the Serbian-born doctor, who is 28, found herself at home looking at a needle loaded with hormones. She pushed it under her skin and pressed the plunger.

Radenkovic wasn’t trying to get pregnant. Instead, she’d signed up for her own company’s medical study of how to “mature” human eggs in a lab dish instead of inside their bodies. In a regular IVF process, women inject powerful hormones twice a day for two weeks in order to hyperstimulate their ovaries and generate a crop of ripe eggs, not just the usual one. And it’s an ordeal: shots hurt, there can be side effects and mood swings, and the drugs cost around $6,000.

Gameto’s process, described last week in the journal Human Reproduction, needs many fewer shots and uses lab-made ovary cells to complete the maturation process in a petri dish. The study involved 67 women, including Radenkovic, and tracked the development of several hundred eggs. Some were fertilized to make embryos, but none were transferred to make a pregnancy. Radenkovic says she joined the study to see how it meshed with her professional schedule.

“I’m not going to recommend it to anybody as a spa day; it’s still a medical procedure,” she says, “But I felt that it was still something I was able to integrate into a busy lifestyle of a start-up CEO who is working pretty hard.”

I’d spoken to Radenkovic a year ago, when she’d told me how she had hired an advisory board and raised funds—important milestones for a young company and a new executive. Like me, though, some of her contacts weren’t aware she’d joined the experiment and hadn’t noticed the Instagram selfie she posted from a medical procedure room, smiling and dressed in a hospital gown.

“It’s like Elon getting into a rocket. That means she’s a badass in my opinion,” says Joe Betts-LaCroix, an angel investor in the company who leads a separate biotech, Retro Biosciences.

Unfair aging

Gameto is among a group of startups that see female fertility as an aging problem. While people are living longer—life expectancy has been slowly rising for a hundred years—that’s not true of women’s reproductive lifespans. Nearly all women run out of eggs during their 40s and menopause follows. Radenkovic believes such “accelerated ovarian aging” is unfair, causing difficult choices between children, careers, and relationships. After a divorce, she notes, a man can start a new family. A woman might not be able to.

“This is a big problem and we are going to fight it with science,” Radenkovic declared in a Twitter thread early last year when she announced becoming CEO of the startup, which had been operating in stealth mode since being incorporated two years earlier by a fertility entrepreneur, Martin Varsavsky, who is still its chairman.

One strategy for fighting ovarian aging is to freeze eggs while you’re young to use them later in life—that can add a decade to a person’s reproductive window. But when Radenkovic considered taking that step a few years ago, she was dissuaded by the time commitment. She was then a new arrival in New York City and juggling three jobs. She decided that people inclined to plan ahead, with $10,000 to spend (that’s about what it costs), “are the ones that are least likely to have the time to fit this into their schedules.”

“I was like, I don’t think I can do this whole process,” she says. “Which is why I felt like probably a lot more women would do it if it was shorter, easier, and cheaper, right?

That experience is what led Randenkovic to push Gameto to work on a better process and, a year later, to try it herself.

During the study, the Forbes 30 Under 30 winner paid special attention to see how well it fit with work and her time on the entrepreneurial circuit, giving talks and leading longevity seminars. In a phone interview, she ticked off a list of the downsides she encountered: one teary, emotional 24 hours when she skipped meetings and one afternoon of constipation brought on by drugs. Plus, the hospital procedure in which a doctor used a probe to scrape off the immature eggs, which involved anesthesia, and caused a painful next ovulation.

“So half a day off work and one day where I would say my productivity at work was not optimal,” she tallies. “This is why we think that this technology for reducing IVF from two weeks, high cost, and medical risks to something you can do over the weekend is a big breakthrough.”

Outside experts are far more cautious—and at least

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By: Antonio Regalado
Title: This biotech CEO decided to take her own (fertility) medicine
Sourced From: www.technologyreview.com/2023/10/16/1081670/gameto-biotech-ceo-fertility-experiment/
Published Date: Mon, 16 Oct 2023 10:00:00 +0000

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The Download: generative AI’s carbon footprint, and a CRISPR patent battle

This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Making an image with generative AI uses as much energy as charging your phone

The news: Generating a single image using a powerful AI model takes as much energy as fully charging your smartphone, according to a new study. This is the first time researchers have calculated the carbon emissions caused by using an AI model for different tasks.

The significance: These emissions will add up quickly. The generative-AI boom has led big tech companies to integrate powerful AI models into many different products, from email to word processing. They are now used millions, if not billions, of times every single day.

The bigger picture: The study shows that while training massive AI models is incredibly energy intensive, it’s only one part of the puzzle. Most of their carbon footprint comes from their actual use. Read the full story.

—Melissa Heikkilä

The first CRISPR cure might kickstart the next big patent battle

By the middle of December, Vertex Pharmaceuticals is expected to receive FDA approval to sell a revolutionary new treatment for sickle-cell disease that’s the first in the US to use CRISPR to alter the DNA inside human cells. (Vertex has already received regulatory approval in the UK.)

But there’s a problem. The US patent on editing human cells with CRISPR isn’t owned by Vertex—it is owned by the Broad Institute of MIT and Harvard, probably America’s largest gene research center, and exclusively licensed to a Vertex competitor, Editas Medicine, which has its own sickle-cell treatment in testing.

That means Editas will want Vertex to pay. And if it doesn’t, Editas and Broad could go to the courts to claim patent infringement, demand royalties and damages, or even potentially try to stop the treatment from being sold. Odds are we’re about to see a blockbuster lawsuit. Read the full story.

—Antonio Regalado

This story is from The Checkup, our weekly newsletter giving you the inside track on all things health and biotech. Sign up to receive it in your inbox every Thursday.

A high school’s deepfake porn scandal is pushing US lawmakers into action

On October 20, Francesca Mani was called to the counselor’s office at her New Jersey high school. A 14-year-old sophomore and a competitive fencer, Francesca wasn’t one for getting in trouble. But it turned out that over the summer, boys in the school had used artificial intelligence to create sexually explicit pictures of some of their classmates. The school administration told Francesca that she was one of more than 30 girls who had been victimized.

Francesca didn’t see the photo of herself that day. And she still doesn’t intend to. Instead, she’s put all her energy into ensuring that no one else is targeted this way.

And, in the past few weeks, her advocacy has already fueled new legislative momentum to regulate nonconsensual deepfake pornography in the US. Read the full story.

—Tate Ryan-Mosley 

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 This is why we’re all sick right now
We’re contending with a lot more illnesses than we did in the pre-covid world. (The Atlantic $)
And covid hasn’t gone away either. (MIT Technology Review)

2 Climate disinformation is a big obstacle to action
And much of it is generated by influential nations, including China and Russia. (NYT $)
The US government has stopped warning social networks about foreign disinformation campaigns. (WP $)

3 Is the Turing Test dead?
It was arguably never that reliable a measure of intelligence to begin with. (IEEE Spectrum)
Mustafa Suleyman: My new Turing test would see if AI can make $1 million. (MIT Technology Review)
Hiring is still hot for prompt engineers, a year since ChatGPT launched. (Bloomberg $)

4 The long-delayed Tesla Cybertruck is finally on sale
And the price tag starts at $60,990. (The Guardian)
It has its detractors. But it has plenty of fans, too. (The Atlantic $)

5 College students are subject to alarming levels of surveillance
Which is adding to their stress levels at an already stressful time in their lives. (The Markup)
Computer scientists at Carnegie Mellon University can’t agree on what privacy means. (MIT Technology Review)

6 How Huawei stunned the US with a new Chinese-made chip
Getting around sanctions will have been difficult, and very expensive. (FT $)
Huawei’s 5G chip breakthrough needs a reality check. (MIT Technology Review)

7 Anduril has launched a wild new jet-powered AI drone
The company says it could be used in Ukraine to intercept Russian drones. (Wired $)

8 Startups have had a bad

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By: Charlotte Jee
Title: The Download: generative AI’s carbon footprint, and a CRISPR patent battle
Sourced From: www.technologyreview.com/2023/12/01/1084204/the-download-ai-carbon-footprint-crispr-battle/
Published Date: Fri, 01 Dec 2023 13:10:00 +0000

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The Download: abandoning carbon offsets, and creating new materials

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This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

The University of California has all but dropped carbon offsets—and thinks you should, too

In the fall of 2018, the University of California tasked a team of researchers with identifying projects from which it could confidently purchase carbon offsets that would reliably cancel out greenhouse gas emissions across its campuses. They found next to nothing.

The findings helped prompt the entire university system to radically rethink its sustainability plans. Now the researchers are sharing the lessons they learned over the course of the project, in the hopes of helping other universities and organizations consider what role, if any, offsets should play in sustainability strategies, MIT Technology Review can report.

The project’s leaders have three main takeaways for what others should do. Read our story to find out what they are.

—James Temple

Google DeepMind’s new AI tool helped create more than 700 new materials

The news: Google DeepMind has created a tool that uses deep learning to dramatically speed up the process of discovering new materials. The technology, which is called graphical networks for material exploration (GNoME), has already been used to predict structures for 2.2 million new materials, of which more than 700 have gone on to be created and tested in the lab.

Why it matters: From EV batteries to solar cells to microchips, new materials can supercharge technological breakthroughs. But discovering them usually takes months or even years of trial-and-error research. Thanks to GNoME, the number of known stable materials has grown almost tenfold, to 421,000. Read the full story.

—June Kim

The X Prize is taking aim at aging with a new $101 million award

Money can’t buy happiness, but X Prize founder Peter Diamandis hopes it might be able to buy better health. The X Prize Foundation, which funds global competitions to spark development of breakthrough technologies, has announced a new $101 million prize—the largest yet—to address the mental and physical decline that comes with aging.

The winners will have to prove by 2030 that their intervention can turn back the clock in older adults by at least a decade in three key areas: cognition, immunity, and muscle function. Its organizers are hoping the large prize will convince hundreds or even thousands of teams to compete. Read the full story.

—Cassandra Willyard

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Ilya Sutskever is leaving the OpenAI board  
But the chief scientist is staying at the firm—for now. (Bloomberg $)
Microsoft has been added as a non voting member of the board. (NYT $)
Sam Altman says he initially felt furious after being asked to return to the company. (The Verge)
Inside the mind of OpenAI’s chief scientist. (MIT Technology Review)

2 Elon Musk isn’t playing nice with X’s worried advertisers
In fact, he went on a foul-mouthed rant railing against them. (CNBC)
Disney boss Bob Iger was a target of Musk’s ire. (WP $)
Musk just can’t help himself. (Slate $)

3 Next year is going to be even hotter
🌡
Thanks, in part, to the El Niño weather phenomenon. (FT $)
Methane is due to be a hot topic at COP28. (Economist $)+ Climate action is gaining momentum. So are the disasters. (MIT Technology Review)

4 Google has agreed to pay Canadian news outlets $100 million a year
It’s a rare win for publishers in their fight to get Big Tech to pay for content. (Motherboard)
Supporters say it’s the first step towards creating a sustainable news ecosystem. (BBC)

5 India is determined to clean up the Ganges river
The sacred waterway is incredibly polluted. Cleaning it up is both a holy and a scientific mission. (Wired $)
El Paso was “drought-proof.” Climate change is pushing its limits. (MIT Technology Review)

6 US border control is planning to trial Palmer Luckey’s AI surveillance towers
The autonomous towers track objects even in the coldest conditions. (404 Media)

7 Inside one man’s mission to track America’s gun violence
No one federal agency charts it, so Dan Kois has stepped up to fill the void. (Bloomberg $)

8 Please don’t follow TikTok’s dating advice
It’s bleak at best, outrageously sexist at worst. (Vox)
Here’s how the net’s newest matchmakers help you find love. (MIT Technology Review)

9 Cutting virtual grass is deeply satisfying
Just ask the video games fans transfixed by maintaining their lawns. (The Guardian)

10 What Spotify

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By: Rhiannon Williams
Title: The Download: abandoning carbon offsets, and creating new materials
Sourced From: www.technologyreview.com/2023/11/30/1084123/the-download-abandoning-carbon-offsets-and-creating-new-materials/
Published Date: Thu, 30 Nov 2023 13:10:00 +0000

Did you miss our previous article…
https://mansbrand.com/sustainability-starts-with-the-data-center/

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Sustainability starts with the data center

MIT Hitachi V5 110723 Cover

When asked why he targeted banks, notorious criminal Willie Sutton reportedly answered, “Because that’s where the money is.” Similarly, when thoughtful organizations target sustainability, they look to their data centers—because that’s where the carbon emissions are.

MIT Hitachi V5 110723 Cover 1

The International Energy Agency (IEA) attributes about 1.5% of total global electricity use to data centers and data transmission networks. This figure is much higher, however, in countries with booming data storage sectors: in Ireland, 18% of electricity consumption was attributable to data centers in 2022, and in Denmark, it is projected to reach 15% by 2030. And while there have been encouraging shifts toward green-energy sources and increased deployment of energy-efficient hardware and software, organizations need to accelerate their data center sustainability efforts to meet ambitious net-zero targets.

For data center operators, options for boosting sustainability include shifting energy sources, upgrading physical infrastructure and hardware, improving and automating workflows, and updating the software that manages data center storage. Hitachi Vantara estimates that emissions attributable to data storage infrastructure can be reduced as much as 96% by using a combination of these approaches.

Critics might counter that, though data center decarbonization is a worthy social goal, it also imposes expenses that a company focused on its bottom line can ill afford. This, however, is a shortsighted view.

Data center decarbonization initiatives can provide an impetus that enables organizations to modernize, optimize, and automate their data centers. This leads directly to improved performance of mission-critical applications, as well as a smaller, denser, more efficient data center footprint—which then creates savings via reduced energy costs. And modern data storage and management solutions, beyond supporting sustainability, also create a unified platform for innovation and new business models through advanced data analytics, machine learning, and AI.

Dave Pearson, research vice president at IDC, says, “Decarbonization and the more efficient energy utilization of the data center are supported by the same technologies that support data center modernization. Modernization has sustainability goals, but obviously it provides all kinds of business benefits, including enabling data analytics and better business processes.”

Download the full report.

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff.

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By: MIT Technology Review Insights
Title: Sustainability starts with the data center
Sourced From: www.technologyreview.com/2023/11/30/1083909/sustainability-starts-with-the-data-center/
Published Date: Thu, 30 Nov 2023 15:03:00 +0000

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