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Michael Edenfield’s doctor calls him the Incredible Shrinking Man.

Between Thanksgiving 2021 and Christmas 2022, the 49-year-old aviation worker shed 129 pounds. Also gone: his sleep apnea machine, his high-blood-pressure medication, and a diuretic pill he had used to alleviate fluid retention in his legs. This is thanks to the only medication Edenfield takes today: Wegovy, a weight-loss drug he injects into his stomach once a week.

Edenfield’s success story is the most popular post on a Reddit forum dedicated to weight-loss injections. Supportive commenters tell him he looks “decades younger” and is “very inspiring.” What you can’t read about—anywhere on the internet—are the experiences of his sister, a 54-year-old restaurant owner named Melissa Hall.

In October 2022, Hall began taking Mounjaro, an injectable diabetes medicine that was prescribed to her off-label as a weight-loss drug. She lost 27 pounds in a month and a half, but after her sixth weekly injection, she awoke feeling as though “I had ripped something in my abdomen, right down the middle.” She was diagnosed with pancreatitis, a sudden inflammation of the pancreas, and continued to experience “stabbing pain” for a week. Though she is now recovered, her doctor refuses to prescribe her Mounjaro again. (Pancreatitis is a known possible side effect of these drugs.)

The Incredible Shrinking Man and his sister are one family with two very different experiences of our current weight-loss injection boom.

Wegovy and Mounjaro became household names in 2022, alongside other relatively young drugs such as Ozempic, Victoza, and Saxenda. Each of these drugs is a GLP-1 receptor agonist (GLP-1 RA), meaning it mimics the hormone glucagon-like peptide 1, which is released after eating and causes a feeling of fullness. Edenfield says Wegovy makes eating less pleasurable, while Hall says Mounjaro “took away any desire to eat”: “I was eating almost nothing, and it was absolutely wonderful.”

Over the course of the last year, these so-called “miracle” weight-loss drugs have blown up across the internet. Celebrity news is made every time someone famous confirms or denies using the shots (Elon Musk: Yes. Khloe Kardashian: No). But these drugs owe much of their fame to social media and discussion boards, where they are promoted by everyday people and virality-chasing influencers alike. On TikTok, videos hashtagged Ozempic have 600 million views. On Facebook, injection support groups accumulate tens of thousands of members. Across social media, influencers promote health-care services that provide compounded, non-branded formulations of these medications, something some obesity specialists have warned against.

When a drug takes over the internet, it of course takes over the world. “People in their 20s, 30s, 40s are interested in what they’ve been seeing on the internet about injections to help lose weight,” says LaTasha Perkins, a family physician at Georgetown University in Washington, DC. Since the winter of 2022, Perkins has seen a moderate increase in inquiries about weight-loss injections. “This time last year I wasn’t having these conversations about these particular drugs,” she says. Now, patients come to her and specifically ask about Ozempic.

Yet not everyone who wants them goes to a doctor. Throughout 2022, rising demand for weight-loss injections caused global shortages. As a result, some people began seeking these drugs illegally, crossing borders or buying them under the counter without a prescription.

Do the hype and the hashtags tell the full story? What are the physical, social, and psychological side effects of a miracle? And can all the publicity lead people to do things they definitely shouldn’t do?

Good side effects, bad side effects

In the beginning, weight loss was just a side effect. GLP-1 RAs were first developed to treat type 2 diabetes; their hormone-mimicking action provokes insulin production. In 2005, the US Food and Drug Administration approved the first drug of this kind, Exenatide, for diabetics. Throughout the 2000s, more and more GLP-1 RAs came onto the market. Right away, patients noticed that these drugs didn’t just treat their diabetes—they also helped them lose weight.

Ozempic and Wegovy, the brand names of a GLP-1 RA known as semaglutide, are both made by Novo Nordisk, a Danish pharmaceutical company. Though they both contain the same active ingredient, the drugs have different indications, dosages, prescribing information, titration schedules, and delivery devices. In 2017, Ozempic was first approved as a diabetes treatment, and doctors soon began to prescribe it off-label to overweight patients. Subsequently, Novo Nordisk developed Wegovy specifically for weight loss. In June 2021, it became the first new treatment for chronic obesity approved by the FDA since 2014.

Then, in May 2022,

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By: Amelia Tait
Title: Weight-loss injections have taken over the internet. But what does this mean for people IRL?
Sourced From: www.technologyreview.com/2023/03/20/1070037/weight-loss-injections-societal-impact-ozempic/
Published Date: Mon, 20 Mar 2023 09:08:46 +0000

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The Download: generative AI’s carbon footprint, and a CRISPR patent battle

This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

Making an image with generative AI uses as much energy as charging your phone

The news: Generating a single image using a powerful AI model takes as much energy as fully charging your smartphone, according to a new study. This is the first time researchers have calculated the carbon emissions caused by using an AI model for different tasks.

The significance: These emissions will add up quickly. The generative-AI boom has led big tech companies to integrate powerful AI models into many different products, from email to word processing. They are now used millions, if not billions, of times every single day.

The bigger picture: The study shows that while training massive AI models is incredibly energy intensive, it’s only one part of the puzzle. Most of their carbon footprint comes from their actual use. Read the full story.

—Melissa Heikkilä

The first CRISPR cure might kickstart the next big patent battle

By the middle of December, Vertex Pharmaceuticals is expected to receive FDA approval to sell a revolutionary new treatment for sickle-cell disease that’s the first in the US to use CRISPR to alter the DNA inside human cells. (Vertex has already received regulatory approval in the UK.)

But there’s a problem. The US patent on editing human cells with CRISPR isn’t owned by Vertex—it is owned by the Broad Institute of MIT and Harvard, probably America’s largest gene research center, and exclusively licensed to a Vertex competitor, Editas Medicine, which has its own sickle-cell treatment in testing.

That means Editas will want Vertex to pay. And if it doesn’t, Editas and Broad could go to the courts to claim patent infringement, demand royalties and damages, or even potentially try to stop the treatment from being sold. Odds are we’re about to see a blockbuster lawsuit. Read the full story.

—Antonio Regalado

This story is from The Checkup, our weekly newsletter giving you the inside track on all things health and biotech. Sign up to receive it in your inbox every Thursday.

A high school’s deepfake porn scandal is pushing US lawmakers into action

On October 20, Francesca Mani was called to the counselor’s office at her New Jersey high school. A 14-year-old sophomore and a competitive fencer, Francesca wasn’t one for getting in trouble. But it turned out that over the summer, boys in the school had used artificial intelligence to create sexually explicit pictures of some of their classmates. The school administration told Francesca that she was one of more than 30 girls who had been victimized.

Francesca didn’t see the photo of herself that day. And she still doesn’t intend to. Instead, she’s put all her energy into ensuring that no one else is targeted this way.

And, in the past few weeks, her advocacy has already fueled new legislative momentum to regulate nonconsensual deepfake pornography in the US. Read the full story.

—Tate Ryan-Mosley 

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 This is why we’re all sick right now
We’re contending with a lot more illnesses than we did in the pre-covid world. (The Atlantic $)
And covid hasn’t gone away either. (MIT Technology Review)

2 Climate disinformation is a big obstacle to action
And much of it is generated by influential nations, including China and Russia. (NYT $)
The US government has stopped warning social networks about foreign disinformation campaigns. (WP $)

3 Is the Turing Test dead?
It was arguably never that reliable a measure of intelligence to begin with. (IEEE Spectrum)
Mustafa Suleyman: My new Turing test would see if AI can make $1 million. (MIT Technology Review)
Hiring is still hot for prompt engineers, a year since ChatGPT launched. (Bloomberg $)

4 The long-delayed Tesla Cybertruck is finally on sale
And the price tag starts at $60,990. (The Guardian)
It has its detractors. But it has plenty of fans, too. (The Atlantic $)

5 College students are subject to alarming levels of surveillance
Which is adding to their stress levels at an already stressful time in their lives. (The Markup)
Computer scientists at Carnegie Mellon University can’t agree on what privacy means. (MIT Technology Review)

6 How Huawei stunned the US with a new Chinese-made chip
Getting around sanctions will have been difficult, and very expensive. (FT $)
Huawei’s 5G chip breakthrough needs a reality check. (MIT Technology Review)

7 Anduril has launched a wild new jet-powered AI drone
The company says it could be used in Ukraine to intercept Russian drones. (Wired $)

8 Startups have had a bad

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By: Charlotte Jee
Title: The Download: generative AI’s carbon footprint, and a CRISPR patent battle
Sourced From: www.technologyreview.com/2023/12/01/1084204/the-download-ai-carbon-footprint-crispr-battle/
Published Date: Fri, 01 Dec 2023 13:10:00 +0000

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The Download: abandoning carbon offsets, and creating new materials

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This is today’s edition of The Download our weekday newsletter that provides a daily dose of what’s going on in the world of technology.

The University of California has all but dropped carbon offsets—and thinks you should, too

In the fall of 2018, the University of California tasked a team of researchers with identifying projects from which it could confidently purchase carbon offsets that would reliably cancel out greenhouse gas emissions across its campuses. They found next to nothing.

The findings helped prompt the entire university system to radically rethink its sustainability plans. Now the researchers are sharing the lessons they learned over the course of the project, in the hopes of helping other universities and organizations consider what role, if any, offsets should play in sustainability strategies, MIT Technology Review can report.

The project’s leaders have three main takeaways for what others should do. Read our story to find out what they are.

—James Temple

Google DeepMind’s new AI tool helped create more than 700 new materials

The news: Google DeepMind has created a tool that uses deep learning to dramatically speed up the process of discovering new materials. The technology, which is called graphical networks for material exploration (GNoME), has already been used to predict structures for 2.2 million new materials, of which more than 700 have gone on to be created and tested in the lab.

Why it matters: From EV batteries to solar cells to microchips, new materials can supercharge technological breakthroughs. But discovering them usually takes months or even years of trial-and-error research. Thanks to GNoME, the number of known stable materials has grown almost tenfold, to 421,000. Read the full story.

—June Kim

The X Prize is taking aim at aging with a new $101 million award

Money can’t buy happiness, but X Prize founder Peter Diamandis hopes it might be able to buy better health. The X Prize Foundation, which funds global competitions to spark development of breakthrough technologies, has announced a new $101 million prize—the largest yet—to address the mental and physical decline that comes with aging.

The winners will have to prove by 2030 that their intervention can turn back the clock in older adults by at least a decade in three key areas: cognition, immunity, and muscle function. Its organizers are hoping the large prize will convince hundreds or even thousands of teams to compete. Read the full story.

—Cassandra Willyard

The must-reads

I’ve combed the internet to find you today’s most fun/important/scary/fascinating stories about technology.

1 Ilya Sutskever is leaving the OpenAI board  
But the chief scientist is staying at the firm—for now. (Bloomberg $)
Microsoft has been added as a non voting member of the board. (NYT $)
Sam Altman says he initially felt furious after being asked to return to the company. (The Verge)
Inside the mind of OpenAI’s chief scientist. (MIT Technology Review)

2 Elon Musk isn’t playing nice with X’s worried advertisers
In fact, he went on a foul-mouthed rant railing against them. (CNBC)
Disney boss Bob Iger was a target of Musk’s ire. (WP $)
Musk just can’t help himself. (Slate $)

3 Next year is going to be even hotter
🌡
Thanks, in part, to the El Niño weather phenomenon. (FT $)
Methane is due to be a hot topic at COP28. (Economist $)+ Climate action is gaining momentum. So are the disasters. (MIT Technology Review)

4 Google has agreed to pay Canadian news outlets $100 million a year
It’s a rare win for publishers in their fight to get Big Tech to pay for content. (Motherboard)
Supporters say it’s the first step towards creating a sustainable news ecosystem. (BBC)

5 India is determined to clean up the Ganges river
The sacred waterway is incredibly polluted. Cleaning it up is both a holy and a scientific mission. (Wired $)
El Paso was “drought-proof.” Climate change is pushing its limits. (MIT Technology Review)

6 US border control is planning to trial Palmer Luckey’s AI surveillance towers
The autonomous towers track objects even in the coldest conditions. (404 Media)

7 Inside one man’s mission to track America’s gun violence
No one federal agency charts it, so Dan Kois has stepped up to fill the void. (Bloomberg $)

8 Please don’t follow TikTok’s dating advice
It’s bleak at best, outrageously sexist at worst. (Vox)
Here’s how the net’s newest matchmakers help you find love. (MIT Technology Review)

9 Cutting virtual grass is deeply satisfying
Just ask the video games fans transfixed by maintaining their lawns. (The Guardian)

10 What Spotify

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By: Rhiannon Williams
Title: The Download: abandoning carbon offsets, and creating new materials
Sourced From: www.technologyreview.com/2023/11/30/1084123/the-download-abandoning-carbon-offsets-and-creating-new-materials/
Published Date: Thu, 30 Nov 2023 13:10:00 +0000

Did you miss our previous article…
https://mansbrand.com/sustainability-starts-with-the-data-center/

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Sustainability starts with the data center

MIT Hitachi V5 110723 Cover

When asked why he targeted banks, notorious criminal Willie Sutton reportedly answered, “Because that’s where the money is.” Similarly, when thoughtful organizations target sustainability, they look to their data centers—because that’s where the carbon emissions are.

MIT Hitachi V5 110723 Cover 1

The International Energy Agency (IEA) attributes about 1.5% of total global electricity use to data centers and data transmission networks. This figure is much higher, however, in countries with booming data storage sectors: in Ireland, 18% of electricity consumption was attributable to data centers in 2022, and in Denmark, it is projected to reach 15% by 2030. And while there have been encouraging shifts toward green-energy sources and increased deployment of energy-efficient hardware and software, organizations need to accelerate their data center sustainability efforts to meet ambitious net-zero targets.

For data center operators, options for boosting sustainability include shifting energy sources, upgrading physical infrastructure and hardware, improving and automating workflows, and updating the software that manages data center storage. Hitachi Vantara estimates that emissions attributable to data storage infrastructure can be reduced as much as 96% by using a combination of these approaches.

Critics might counter that, though data center decarbonization is a worthy social goal, it also imposes expenses that a company focused on its bottom line can ill afford. This, however, is a shortsighted view.

Data center decarbonization initiatives can provide an impetus that enables organizations to modernize, optimize, and automate their data centers. This leads directly to improved performance of mission-critical applications, as well as a smaller, denser, more efficient data center footprint—which then creates savings via reduced energy costs. And modern data storage and management solutions, beyond supporting sustainability, also create a unified platform for innovation and new business models through advanced data analytics, machine learning, and AI.

Dave Pearson, research vice president at IDC, says, “Decarbonization and the more efficient energy utilization of the data center are supported by the same technologies that support data center modernization. Modernization has sustainability goals, but obviously it provides all kinds of business benefits, including enabling data analytics and better business processes.”

Download the full report.

This content was produced by Insights, the custom content arm of MIT Technology Review. It was not written by MIT Technology Review’s editorial staff.

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By: MIT Technology Review Insights
Title: Sustainability starts with the data center
Sourced From: www.technologyreview.com/2023/11/30/1083909/sustainability-starts-with-the-data-center/
Published Date: Thu, 30 Nov 2023 15:03:00 +0000

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